用于治疗胃癌的靶向药物进展

Advances in Targeting Drugs for Accurate Therapy of Gastric Cancer

胃癌是全球发病率第五位的恶性肿瘤,致死率仅次于肺癌、肝癌居第三位。化疗是目前进展期胃癌的主要治疗手段,但其联合化疗方案并没有从根本上提高化疗有效率。通过对胃癌发生、发展、复发和转移过程中分子生物机制的研究,分子靶点药物治疗应运而生,分子靶向治疗很大程度上提高了胃癌治疗的有效率。本文主要综述了胃癌靶点及其相关靶向药物。

Gastric cancer is the fifth global incidence of malignant tumors,lethal rate ranks third,which is just after lung cancer and liver cancer. Chemotherapy is currently the main treatment of advanced gastric cancer, but the combined chemotherapy couldn t improve treatment efficiency fundamentally. Molecular target drug therapy is born at the right time through studying the molecular biological mechanism in the occurrence, development,recurrence and metastasis of gastric cancer. In this paper, the gastric cancer target and related drugs was summarized.