非酒精性脂肪性肝病患者血清铁蛋白水平变化及临床意义

Changes of serum ferritin and clinical significance in patients with nonalcoholic fatty liver disease

目的:研究血清铁蛋白(SF)在非酒精性脂肪性肝病(NAFLD)患者中的水平变化及其临床意义。方法:选取96例NAFLD患者和100例体检健康者进行血清SF和血清生化学指标检查,分析并评价SF在NAFLD患者的变化及与其他指标的相关性。结果:NAFLD患者体质量指数(BMI)、腰围、丙氨酸氨基转移酶(ALT)、γ-谷氨酰转移酶(γ-GT)、总胆固醇(TC)和三酰甘油(TG)明显高于健康者,差异有统计学意义(P<0.05);NAFLD患者血清铁蛋白(SF)高于健康者,差异有统计学意义(P<0.05)。相关性分析结果显示,SF与ALT、AST、γ-GT呈显著正相关(P<0.05),与TG、TC无相关(P<0.05)。结论:血清SF水平与NAFLD患者肝功能水平相关,联合相关指标检测有助于判断NAFLD患者肝损伤的进展。

Objective：To study the changes of serum ferritin and clinical significance in patients with nonalcoholic fatty liver disease （NAFLD）. Methods：The serum ferritin （SF） and serum biochemical markers were examined in 96 NAFLD patients and 100 healthy sub- jects. To analyze and evaluate the changes of SF in patients with NAFLD and the correlation with other indexes. Results ： NAFLD patients with body mass index （BMI）, waist circumference, ALT, γ-GT,TC,TG were higher than those of healthy controls, the difference was statistically significant （P 〈 0.05）. The serum ferritin （SF） in patients with NAFLD was higher than that in healthy subjects, and the difference was statistically significant （P 〈 0.05 ）. Correlation analysis showed that SF was positively correlated with ALT, AST and γ-GT （P 〈 0.05）, and no correlation with TG and TC （P 〈 0.05 ）. Conclusion： The level of serum SF was correlated with the level of liver function in patients with NAFLD, and the detection of associated indexes was helpful to judge the progress of liver injury in patients with NAFLD.