130例大疱性类天疱疮患者系统性疾病发生情况分析

Analysis of prevalence of systemic diseases in 130 patients with bullous pemphigoid

目的:分析130例大疱性类天疱疮(BP)住院患者神经系统疾病、糖尿病、高血压、冠心病、心律失常及慢性肾功能衰竭等系统性疾病的发生情况及危险因素分析。方法:对130例BP住院患者(BP组)及130例同期年龄及性别相匹配的其他皮肤病患者(对照组)的临床资料进行回顾性病例对照分析。并将系统性疾病作为变量进行单因素和多因素Logistic回归分析。结果:BP组中神经系统疾病主要为脑卒中、痴呆、帕金森病和癫痫。单因素分析显示脑卒中(30%)和痴呆(6.1%)的发生率高于对照组,两组差异有统计学意义(P=0.001,P=0.042)。多因素Logistic回归分析显示脑卒中是BP的独立危险因素[OR=2.722,95%CI(1.436~5.160),P=0.002]。BP组中糖尿病、心律失常、慢性肾功能衰竭、高血压及慢性阻塞性肺疾病的发生率均高于对照组,但差异无统计学意义(P>0.05)。恶性肿瘤在BP组的发生率低于对照组,两者差异无统计学意义(P>0.05)。结论:脑卒中与BP具有相关性。采用多专科合作的综合管理措施,对优化BP的治疗有重要意义。

Objective： To investigate the prevalence of systemic diseases, which including neurological diseases, diabetes, hypertension, coronary heart disease, arrhythmia and chronic renal failure, in 130 patients with bullous pemphigoid. Methods： This was a retrospective case-control study involving 130 patients with bullous pemphigoid（BP group） and 130 age-sex matched controls, and setting these systemic diseases as variables for univariate and multivariate logistic regression analysis. Results： The main neurological diseases in the BP group were stroke, dementia Parkinson＇s disease and epilepsy. Univariate logistic regression analysis showed that the incidence rate of stroke（30%） and dementia（6.1%） was higher than that of the control group （P=0.001 and P=0.042, respectively）. Multivariate logistic regression analysis showed that stroke is major risk faetors for BP patients[OR=2.722,95%CI（1.436-5.160）,P=0.002]. The incidence of diabetes, cardiac arrhythmia, chronic renal failure, hypertension and chronic obstructive pulmonary disease were higher than that in the control group, but the difference was not statistically significant between the two groups （P〉0.05）. The incidence of malignancy in the BP group was lower than that in the control group, the difference was also not statistically significant（P〉0.05）. Conclusion： Stroke is correlated with bullous pemphigoid. It is imperative to adopt a holistic approach to patient care in view of the increased rates of neuro-logical disorders among bullous pemphigoid patients. The use of multi-disciplinary cooperation in the comprehensive management measures to optimize the treatment of bullous pemphigoid treatment is important.