女性尖锐湿疣患者宫颈人乳头瘤状病毒和沙眼衣原体感染的流行病学调查

Epidemiological investigation of HPV and Chlamydia trachomatis infection on cervical samples of women with condyloma acuminatum

目的:总结性病门诊女性尖锐湿疣(CA)患者并发泌尿生殖道沙眼衣原体(Ct)的流行病学资料,了解该组患者宫颈有无人乳头瘤状病毒(HPV)感染及HPV基因分型。方法:收集确诊为尖锐湿疣的女性宫颈脱落细胞样本,检测HPV DNA分型及Ct的DNA。结果:123例女性CA患者宫颈样本中HPV、Ct及共同感染率分别是88.6%(109/123)、22.7%(20/88)及22.7%(20/88)。其中高危型HPV感染者占75.6%(93/123),最常见的亚型为HPV-16、52、18、51、58。65.0%(80/123)表现为混合HPV感染;13.0%(16/123)仅为低危HPV感染;10.6%(13/123)仅为高危HPV感染。结论:该组22.7%的CA女性患者宫颈并发Ct感染,88.6%并发宫颈HPV感染,其中高危型达75.6%。在CA女性患者中开展Ct及宫颈HPV检测很有必要。

Objective： To summarize the epidemiological data of chlamydia trachomatis（Ct） and human papillomavirus（HPV） co-infection in urogenital tract of patients with condyloma acuminate （CA） and to investigate the presence of HPV infection and HPV genotyping in those patients. Methods： Cervical exfoliated cell samples of female patients diagnosed as CA were collected. PCR was performed to detect the DNA of HPV and Ct. Results： The prevalence of cervical HPV, Ct and co-infection was 88.6%（109/123）, 22.7%（20/88）, and 22.7%（20/88） respectively. 75.6%（93/123） cases presented with HR-HPV infection, 65.0%（80/123） were multiple genotypes infection, 13.0%（16/123） single LR-HPV genotype and 10.6%（13/123） single HR-HPV genotype, with HR-HPV 16, 52, 18, 51, 58 and LR-HPV 11, 6 being the most common HPV genotypes. Conclusion： 22.7% of female patients with CA were infected with chlamydia trachomatis, and 88.6% with cervical HPV infection, of which HR-HPV infection accounted for 75.6%. It is necessary to carry on Ct and cervical HPV detection in female CA patients.