瑞舒伐他汀在急性脑梗死患者中的应用效果研究

Study of the Application Effect of Rosuvastatin in Patients with Acute Cerebral Infarction

目的:探讨瑞舒伐他汀治疗急性脑梗死患者临床效果。方法:回顾性选取笔者所在医院接诊的急性脑梗死患者117例,按照用药方式的不同,分为两组,常规组57例患者采用常规溶栓治疗;研究组60例患者在常规组治疗基础上加用瑞舒伐他汀治疗。于治疗后4周比较治疗前后两组患者的脑部血栓溶解情况、血脂水平及血液流变学指标的变化。结果:患者脑部CT检查可见研究组血栓溶解效果明显优于常规组,研究组患者的血脂水平代谢情况比常规组明显改善,同时血液流变学指标也比常规组降低明显,差异均有统计学意义(P<0.05)。结论:常规溶栓加用瑞舒伐他汀治疗急性脑梗死,对患者脑部血栓的有效溶解、降低血脂水平具有显著的临床效果,是一种安全有效、降低疾病风险的用药方案。

Objective： To explore the clinical effect of Rosuvastatin in the treatment of acute cerebral infarction.Method： 117 patients with acute cerebral infarction admitted to our hospital were retrospectively chosen.They were divided into two groups according to the way of medication.There were 57 patients in the conventional group and were given routine thrombolytic therapy.60 patients in the study group were given Rosuvastatin treatment on the basis of the conventional group.The changes of thrombolysis, blood lipid and hemorheology after 4 weeks of treatment in two groups were compared.Result： There were significant thrombolytic effects in the CT scan of the study group.The lipid metabolism in the study group improved better than the conventional group, and the hemorheology indexes of the study group were lower than those of the conventional group（P〈0.05）.Conclusion： The treatment of acute cerebral infarction patients with Rosuvastatin has significant clinical effect in dissolution of cerebral thrombosis, lower blood lipid levels, and it is a safe and effective drug use.