间质性肺疾病急性加重患者的病原学检测

Analysis of the Results of Pathogenic Detection in Patients with Acute Exacerbation of Interstitial Lung Disease

目的分析间质性肺疾病急性加重患者的病原学检测结果。方法选取2012-2016年收治的420例间质性肺疾病急性加重患者,对患者的病原学检查资料进行回顾性分析。结果 420例的病原学检查率大约为42.7%;235例曾经进行血清肺炎支原体抗体检测,其阳性率大约为24.7%;免疫抑制剂对痰培养影响,差异无统计学意义(P>0.05)。结论间质性肺疾病急性加重患者的主要病原体是肺炎支原体和巨细胞病毒。细菌感染主要是革兰阴性菌,但是真菌也相对常见。病原学的分布差异没有对患者肺功能和免疫抑制剂应用状况造成显著影响。

Objective To study the etiology of patients with acute exacerbation interstitial lung disease. Methods 420 cases of acute exacerbation interstitial lung disease in our hospital who accepted treatment during 2012 to 2016 were analyzed retrospectively. Results420 cases of etiological examination rate of about 42.7%, 235 cases had serum mycoplasma pneumoniae antibody detection, the positive rate of about 24.7%. Immunosuppressive agents had no statistically significant effect on sputum culture（P〉0.05）. Conclusion Mycoplasma pneumoniae and cytomegalovirus are the major pathogens in patients with acute exacerbation interstitial lung disease. Gram negative bacteria are the main pathogens of bacterial infection, but fungi are relatively common. There is no significant effect on the distribution of pathogens in patients with pulmonary function and immunosuppressive agents.