心肌钙蛋白T和氨基末端脑钠肽前体临床检测对急性心肌梗死患者的意义

The clinical significance of cTnT and NT-proBNP in AMI patients

目的探析急性心肌梗死(AMI)患者早期诊治中血清心肌钙蛋白T(cTnT)和氨基末端脑钠肽前体(NTproBNP)的临床检测意义。方法分析2013年5月至2015年10月在我院接受治疗的118例高度疑似AMI患者的临床资料。根据临床诊断将入选者分成观察组(AMI患者,62例)和对照组(非AMI患者,56例)两组。比较两组患者的一般资料、cTnT、NT-proBNP水平以及cTnT、NT-proBNP单项及两者联合检测价值。结果两组患者的一般资料组间比较均无统计学差异(P>0.05)。观察组患者的cTnT、NT-proBNP水平明显较对照组高(P<0.01)。cTnT、NT-proBNP单项检测的敏感性(82.3%,83.95%)明显低于联合检测(91.9%),特异性(78.6%,82.1%)也明显较联合检测(92.9%)低(P<0.05)。结论血清cTnT与NT-proBNP的联合检测在AMI患者的早期诊断中发挥了重要作用,具有较高的特异性和敏感性,值得推广。

Objective Our retrospective study was aimed toanalyze the clinical detective significance of the serum cTnT and NT-proBNP in early diagnosing patients with AMI.Methods Clinical data of 118 patients with highly suspected AMI received treatment at our hospital from May 2013 to October 2015 was retrospectively analyzed.Patients included were divided into two groups according to the diagnosis,observe group（AMI patients,62 cases）and control group（non-AMI patients,56 cases）.The general information,the levels of cTnT and NT-proBNP and the detective value of the specificity detected lonely（cTnT and NT-proBNP）and combined detection of cTnT and NT-proBNP.Results The general information in two groups had no statistical difference（P〉0.05）.The levels of cTnT and NT-proBNP in observe group were obviously higher than those in control group（P〈0.01）.The sensitivity and specificity of cTnT（82.3%,78.6%）and NT-proBNP（83.95%,82.1%）were obviously lower than those of combined detection of cTnT and NT-proBNP（91.9%,92.9%）（P〈0.01）.Conclusion The combined detection of cTnT and NT-proBNP plays an important role in early diagnosis of AMI patients,which has higher sensitivity and specificity.It＇s worth promoting.