超嗜热古菌的ATP非依赖型蛋白酶和肽酶研究进展

ATP-independent proteases and peptidases from hyperthermophilic archaea

蛋白酶和肽酶在超嗜热古菌的营养代谢、蛋白质转换与加工以及蛋白质质量控制等重要生物学过程中发挥关键作用。超嗜热古菌蛋白酶和肽酶具有优良的热稳定性和高温活性,是研究蛋白质耐热分子机制和酶行使功能上限温度等科学问题的理想材料,同时也具有重要的工业应用价值。本文对超嗜热古菌的ATP非依赖型蛋白酶和肽酶的种类、功能、催化特性、热稳定机制以及应用前景进行综述与分析。

Proteases and peptidases play important roles in nutrient metabolism,protein turnover and processing,and protein quality control in hyperthermophilic archaea.Due to their high stability and activity at high temperatures,proteases and peptidases from hyperthermophilic archaea are especially valuable to study mechanisms that stabilize protein structure and function at the maximum temperature capable of supporting life,and have great potential in industrial application.This review summarizes types,functions,catalytic properties,thermostabilizing mechanisms,and application potential of ATP-independent proteases and peptidases from hyperthermophilic archaea.