钾通道与自噬

Potassium channels and autophagy

K^+通道是广泛分布于细胞膜上、亚型众多的一类离子通道,它们通过参与静息电位形成、物质运输、酶活性和胞间通讯等过程影响细胞的多种生理功能。自噬是机体维持细胞内代谢平衡的一种重要机制,自噬的异常会导致多种疾病的发生和发展。新近文献报道,钾通道与细胞的自噬密切相关。本文简要综述了K^+通道调节自噬通路、自噬通量或自噬溶酶体形成等方面的研究进展,并探讨了K^+通道调控细胞自噬的生理学意义。

Potassium channels have multitudinous subtypes, which are widely distributed on cell membranes. They affect various cellular physiological functions through participating in processes such as resting potential formation, substance transportation, enzyme activity and cellular communication. Autophagy is a significant mechanism to maintain intracellular metabolic homeostasis. The abnormity of autophagy may lead to the occurrence and development of multiple diseases. Recently, it has been reported that K＋ channels and cell autophagy are closely related. Here, we reviewed the recent research progresses on regulation of autophagy signaling, autophagy flux or autophagolysosome formation by K＋ channel, and discussed the physiological significance of autophagy regulation by K~ channel.