摘要
为了降低丝裂霉素C(MMC)在治疗翼状胬肉时经角膜吸收所导致的副作用,将其与DHA偶联为前药DHA-MMC。经离体角膜透过性实验及体外释放实验,结果发现:增大的相对分子质量可阻断MMC的角膜吸收,以避免其眼内副作用;MMC可以前药(DHA-MMC)形式积聚在眼表后逐渐释放MMC以产生活性。
In order to reduce the side effects of mitomycin C （MMC） by corneal absorption in the treat- ment of pterygium,the prodrug DHA -MMC was preparaed by chemical coupling with DHA and MMC. The results of the corneal permeability experiment and in vitro release experiment showed that increased relative molecular weight could block MMC＇s corneal absorption, The prodrug DHA -MMC could amass in ocular surface and then so as to avoid its ocular side effects. release the MMC to generate activity.
出处
《中国油脂》
CAS
CSCD
北大核心
2017年第8期108-110,115,共4页
China Oils and Fats
基金
陕西省教育厅专项科研计划项目(15JK1620)
