补中助长颗粒治疗学龄前特发性身材矮小20例临床观察

Clinical observation on 20 cases of idiopathic short stature in preschool children treated with Buzhong Zhuzhang Granules

目的观察补中助长颗粒治疗学龄前特发性身材矮小(ISS)的临床疗效。方法将40例学龄前ISS患儿随机分为对照组和治疗组,对照组给予生活方式干预,治疗组在对照组治疗方法的基础上口服补中助长颗粒,2次/d,4个疗程后比较2组患儿身高(H)、身高增长速度(GV)、身高标准差计数(Ht SDS)、体质量指数(BMI)、年龄/骨龄(CA/BA)、预测成人身高(PAH)的差异以及血清胰岛素样生长因子1(IGF-1)、生长激素激发试验所得生长激素峰值(GHP)的变化。结果治疗后2组BMI,CA/BA比较,差异均无统计学意义(P>0.05),治疗组GV、PAH、血清IGF-1、GHP、Ht SDS高于对照组,差异均有统计学意义(P<0.05或P<0.01)。结论补中助长颗粒能够促进ISS患儿生长,刺激ISS患儿血清IGF-1和生长激素(GH)的表达可能是其作用机制之一。

Objective To observe the clinical effect of idiopathic short stature （ISS） in preschool children trea- ted with Buzhong Zhuzhang Granules. Methods 40 cases of preschool children with ISS were randomly divided in- to control group and therapy group. The control group was given lifestyle intervention, while the therapy group was given Buzhong Zhuzhang Granule twice a day based on the therapy of control group. After 4 courses of treatment, da- ta of children＇s H,GV,HtSDS, BMI, CA/BA,PAH and changes of IGF-1, GHP were observed and compared. Re- sults After treatment, there were no statistical significant differences in comparison of BMI, CA/B of two groups （P〉0.05）. The degree of GV, PAH, IGF-1, GHP, HtSDS in the therapy group were higher than that of control group,differences had statistical significance （P〈0.05 or P〈0.01 ）. Conclusion Buzhong Zhuzhang Granules can improve ISS,stimulate IGF-1 and GH.