血清半乳糖凝集素-3及C-反应蛋白水平与冠心病患者冠状动脉Gensini评分相关性分析

Relationship of blood level of galectin-3,C-reactive protein and the Gensini score of coronary lesions in patients with coronary artery disease

目的 探讨血清半乳糖凝集素-3（Galectin-3）及C-反应蛋白水平（CRP）与冠心病患者冠状动脉病变程度评分的相关性.方法 选择冠心病患者113例作为研究对象,另选冠状动脉造影结果正常42例作为对照组,将冠心病患者分为稳定型心绞痛组（SAP）、不稳定型心绞痛组（UAP）及急性心肌梗死组（AMI）,根据 Gensini评分的四分位数将冠心病患者分为第一四分位数亚组、第二四分位数亚组、第三四分位数亚组及第四四分位数亚组,比较各组间患者血清Galectin-3及CRP水平,分析血清Galectin-3及CRP水平与冠状动脉Gensini评分的相关性.结果 对照组、SAP、UAP及AMI组患者血清Galectin-3及CRP水平比较差异有统计学意义（F=19.922、9.645,P=0.000、0.009）,且组间两两比较差异亦有统计学意义（P〈0.01）.不同 Gensini 积分组之间Galectin-3及CRP水平比较差异有统计学意义（F=69.803、4.267,P=0.000、0.024）,组间两两比较差异均有统计学意义（P〈0.05）.血清Galectin-3及CRP水平与冠状动脉Gensini评分呈正相关（R=0.745、0.769,P=0.000、0.000）.结论 血清Galectin-3及CRP水平可以作为评价冠心病患者冠状动脉病变程度的参考指标,具有较高的临床价值,值得进一步探讨.

Objective To investigate the relationship of blood level of galectin-3, C-reactive protein and the severity of coronary lesions in patients with coronary artery disease.Methods The 113 patients with coronary heart disease were divided into stable angina group （stable angina, SA）, unstable angina group （unstable angina, UA） and acute myocardial infarction group （acute myocardial infarction, AMI）, and the control group with 42 cases were normal in coronary angiography.There were 1st quartile group, 2nd quartile group, 3rd quartile group and 4th quartile group according to the quartile of Gensini score.The blood levels of Galectin-3 and CRP were examined, the relationship between galectin-3,CRP and the Gensini score were analyzed.Results The blood levels of Galectin-3 and CRP were significantly different in SAP, UAP, AMI groups and control group（F=19.922,9.645, P=0.000,0.009）, and each group also had difference （P〈0.01）.There were significant differences in the levels of galectin-3 and CRP among different Gensini score groups（F=69.803,4.267, P=0.000,0.024）, each group also had significant difference （P〈0.05）.The blood levels of galectin-3, CRP were positively correlated with Gensini score （R=0.745,0.769, P=0.000, 0.000）.Conclusions The blood levels of galectin-3 and CRP can be used as a reference index for the assessment of severity of coronary lesions in patients with coronary artery disease, has a high clinical value, and is worth to further discussion.