干燥综合征70例临床分析

Clinical analysis of Sjogren＇s syndrome with 70 cases

目的 分析干燥综合征的临床特点,为早期诊断提供依据.方法 选择2015年1月至2016年6月符合2012年美国风湿病学会诊断标准的70例干燥综合征患者,对其一般情况、临床症状、系统损伤、辅助检查等进行回顾性分析.结果 70例干燥综合征患者以中老年女性多见.口干（81.43%）和眼干（58.57%）是最常见的临床症状,口腔检查发现87.14%的患者有6颗及以上的龋齿,58.57%患者罹患龋齿超过10年.患者中有自身免疫病家族史者占11.43%.合并血液系统损伤者占48.57%,肺损伤44.28%,甲状腺功能损伤18.57%.唇腺活检阳性率为74.29%.结论 干燥综合征以女性多见,临床表现形式复杂多样,有一定的遗传因素,同时会引起多系统损伤.

Objective To analyze the clinical symptom and system damage of Sjogren＇s syndrome, in order to provide evidence for the preliminary diagnosis of Sjogren＇s syndrome.Methods Seventy patients who fulfilled the 2012 American College of Rheumatology criteria for Sjogre＆＇s syndrome from January 2015 to June 2016 were selected, the general situation, clinical symptoms, systemic damage and auxiliary examination were retrospectively analyzed.Results Among the 70 patients, females are more than males.The onset symptoms usually include dry eyes （81.43%） and dry mouth（58.57%）.Oral examination found that 87.14% of the patients had more than 6 dental caries and 58.57% of the patients had suffered from dental caries for more than 10 years.Sjogren＇s syndrome with system injury consisted of the involvement of hematological system （48.57%）, involvement of lung（44.28%）, and involvement of thyroid（18.57%）.Conclusions The number of male patients with Sjogren＇s syndrome is much lower than female.Clinical manifestations are complex and diverse in forms.It primarily includes controlled exocrine damage such as early dental caries, dry eyes and dry mouth.Sjogren＇s syndrom can lead to systemic damage and it has inheritance intention.