多囊卵巢综合征内分泌异常与CD8＋CD28＋/CD8＋CD28-T细胞平衡的关系

Relationship between uroendocrine abnormality and CD8＋CD28＋/CD8＋CD28-T cell balance of polycystic ovary syndrome

目的 探讨多囊卵巢综合征内分泌异常与CD8＋CD28＋/CD8＋CD28-T细胞平衡的关系.方法 选取2014年12月至2015年9月30例多囊卵巢综合征患者为观察组,同时期30名健康妇女为对照组,检测两组CD8＋CD28＋T、CD8＋CD28-T及其胞内细胞因子、激素水平,比较轻度、中度及重度患者的检测结果,同时分析其相关性.结果 观察组CD8＋CD28＋T、干扰素-γ（IFN-γ）、白细胞介素-2（IL-2）、白细胞介素-10（IL-10）及白细胞介素-12（IL-12）均低于对照组,CD8＋CD28-T、白细胞介素-4（IL-4）、白细胞介素-15（IL-15）及血清睾酮（T）、雌二醇（E2）、泌乳素（PRL）、促黄体生成素（LH）均高于对照组,且观察组轻度、中度及重度患者之间比较差异也有统计学意义（P均〈0.05）.CD8＋CD28＋T与IFN-γ、IL-2、IL-10、IL-12呈正相关,CD8＋CD28-T细胞与IL-4、IL-15及血清T、E2、PRL、LH呈正相关.结论 多囊卵巢综合征呈现内分泌异常及CD8＋CD28＋/CD8＋CD28-T细胞失衡,疾病的发生发展与本类变化有密切的关系.

Objective To investigate the relationship between uroendocrine abnormality and CD8＋CD28＋/CD8＋CD28-T cell balance of polycystic ovary syndrome.Methods Thirty patients with polycystic ovary syndrome from December 2014 to September 2015 were selected as the observation group, 30 cases healthy women at the same time were selected as the control group, then the CD8＋CD28＋,CD8＋CD28-T and its intracellular cytokines, hormones levels of the two groups were compared, and the detection results of patients with mild, moderate and severe disease were compared, then the relativity was analyzed.Results The CD8＋CD28＋T, IFN-γ, IL-2, IL-10 and IL-12 of observation group were all lower than those of the control group, the CD8＋CD28-T, IL-4, IL-15 and serum T, E2, PRL, LH were all higher than those of control group, and the differences of observation group with mild, moderate and servere disease were obvious（all P〈0.05）.The CD8＋CD28＋T was positively correlated with IFN-γ, IL-2, IL-10, IL-12, the CD8＋CD28-T was positively correlated with IL-4, IL-15 and serum T, E2, PRL, LH.Conclusions The patients with polycystic ovary syndrome show abnormal uroendocrine abnormality and CD8＋CD28＋/CD8＋CD28-T cell imbalance, and the development of disease has close relationship with the changes.