心绞痛患者LDL/HDL、中性粒细胞/淋巴细胞比值与其冠状动脉病变程度的关系

The relationship among LDL/HDL and neutrophil/lymphocyte ratio and the severity of coronary artery disease in patients with angina pectoris

目的探讨分析不稳定型心绞痛患者血低密度脂蛋白(LDL)/高密度脂蛋白(HDL)、中性粒细胞/淋巴细胞比值水平与其冠状动脉病变程度的关系,并分析冠状动脉病变的危险因素。方法采用前瞻性对照分析方法,选取不稳定性心绞痛患者124例,依据Gensini评分将患者分为重度组(≥30分)和轻度组(<30分);另选取经脉状动脉造影结果正常者30例为对照组。调查所有受试者完整临床资料,并采用血细胞分析仪或全自动生化分析仪检测其白细胞、淋巴细胞、中心粒细胞计数以及LDL、HDL、甘油三酯、总胆固醇水平,计算LDL/HDL和中心粒细胞/淋巴细胞比值,比较分析其差异及意义。结果轻度组LDL/HDL为(2.1±0.3),中心粒细胞/淋巴细胞为(2.3±0.4);重度组分别为(2.9±0.4)、(3.7±0.6);对照组分别为(1.5±0.3)、(1.5±0.2)。轻度组LDL/HDL和中心粒细胞/淋巴细胞比值高于对照组(P<0.05),但低于重度组(P<0.05)。多因素Logistic分析显示,LDL/HDL(OR=1.857,95%CI=1.714-1.989)和中心粒细胞/淋巴细胞比值(OR=1.548,95%CI=1.269-1.762)是不稳定心绞痛患者冠状动脉严重病变的独立危险因素。结论 LDL/HDL和中心粒细胞/淋巴细胞比值可对不稳定心绞痛患者冠状动脉病变程度进行反映。

Objective To investigate the relationship among LDL/HDL and neutrophil/lymphocyte ratio and the severity of coronary artery disease in patients with angina pectoris. And explore the risk factors of coronary artery disease. Methods 124 cases of unstable angina patients were selected and divided into severe group （Gensini scores equal to or more than 30） and mild group （Gensini scores less than 30）, and 30 cases with normal vein angiography results were enrolled as control group. To investigate the clinical data of all subjects, and the white blood cell, lymphocyte, granulocyte count, LDL, HDL, triglyceride and total cholesterol were detected by blood cell analyzer or automatic biochemistry analyzer, the LDL/HDL and granulocytes/lymphocytes ratio were calculated, the difference and significance were compared and analyzed.Results The LDL/HDL was （2.1 ± 0. 3）, granulocytes/lymphocytes ratio was （2.3±0.4） in mild group, and these were （2.9±0.4） and （3.7±0.6） in severe group respectively, and （ 1.5 ± 0.3 ） and （ 1.5 ± 0.2 ） in control group. The ratio of LDL/HDL and in mild group was higher than that in control group （P〈0.05）, but lower than severe group （P〈0.05）. Multivariate Logistic analysis showed that LDL/HDL（OR= 1.857,95%CI= 1.714-1.989） and granuloeytes/lymphocytes ratio （ OR = 1.548,95% CI = 1.269-1.762） were independent risk factors for coronary artery disease in patients with unstable angina pectoris.Conclusions The ratio of LDL/HDL and granulocytes/ lymphoeytes ratio can refleet the degree of coronary artery disease in patients with unstable angina pectoris.