不孕症患者子宫内膜容受性的评估及改善研究

Research for the assessment and improvement of endometrial receptivity in infertile women

在辅助生殖技术(assisted reproductive technology,ART)中,优质的胚胎、良好的子宫内膜容受性(endometrial receptivity,ER)以及胚胎和子宫内膜的同步发育是影响胚胎成功植入的三个关键因素,多项研究表明移植失败的主要原因是ER的欠缺,而胚胎因素仅占三分之一,因此如何提高胚胎着床率已成为辅助生殖领域讨论的焦点。本文对目前国内外在ER评估和改善这两方面的进展进行综述,以期对临床决策有所帮助。

In assisted reproductive technology （ART）, there are three critical factors which are high-quality embryos, good endometfial receptivity （ER） and the synchrony between the blastocyst and the endometrium largely affecting the successful implantation of embryos. A large number of studies indicate that the main cause of implanta- tion failure is the defect of endometrial receptivity, and the embryos accounted for one third. Therefore, how to improve the implantation rate has been a focus issuse in the assisted reproductive field. This paper mainly reviewed the latest progress in China and abroad about the assessment and improvement of endomelrial receptivity, which is hoped to contribute to clinicians.