梅毒血清固定患者血清IL-10和IL-12水平及其关系研究

Study on serum levels of IL-10 and IL-12 in patients with syphilis and their relationship

目的:比较健康者、梅毒未治疗、梅毒治疗后转阴以及梅毒血清固定患者的血清IL-10和IL-12水平,并分析梅毒血清固定患者血清IL-12、IL-10水平之间的关系。方法:纳入健康者、梅毒未治疗、梅毒治疗后转阴以及梅毒血清固定患者各20例,检测并比较各组的血清IL-12、IL-10水平,并对梅毒血清固定患者血清IL-12、IL-10水平相关性进行分析。结果:对各组的IL-10水平进行检测和比较,各组间比较差异具有统计学意义(P<0.05)。对各组的IL-12水平进行检测和比较,各组间比较差异不具有统计学意义(均P>0.05)。对20例梅毒血清固定患者血清IL-12、IL-10水平之间的关系进行分析,可得二者之间无显著相关性(r=0.423,P>0.05)。结论:梅毒血清固定患者体内会出现免疫失衡,细胞免疫受到抑制,进而导致梅毒螺旋体逃脱机体免疫监视发生残存,是导致血清固定的重要因素之一。

Objectives：To compare the serum IL-10 and IL-12 levels of healthy persons,and syphilis untreated,syphilis negative after treatment and the syphilis serofast patients,to analyze the relationship between serum IL-12 and IL-10 levels in serum syphilis patients.Methods：Four groups were recruited in the study,each of 20 cases.The serum IL-12 and IL-10 levels were detected and compared between the four groups,to analyze the correlation of serum IL-12 and IL-10 level in syphilis serofast patients.Results：Differences in the IL-10 levels among the four groups were statistically significant（P 〈 0.05）,while difference in IL-12 levels was not statistically significant（all P 〉 0.05）.The relationship between serum levels of IL-12 and IL-10 in the 20 syphilis serofast patients was not significant（r = 0.423,P 〉 0.05）.Conclusion：Syphilis serofast patients are likely to encounter immune imbalance,leading to cell immunity inhibited and lake of immune surveillance,which is one of the important factors leading to the serum immobilization.