GSTM1、GSTT1基因多态性与亚洲男性特发性不育症易感性相关性Meta分析

Correlation of the glutathione S-transferase gene polymorphism(GSTM1 and GSTT1) and the Asian male idiopathic infertility:a meta-analysis

目的:探讨人群谷胱甘肽S-转移酶基因多态性与亚洲男性特发性不育易感性的关系。方法:检索pubmed,sciencedirect,springer,China biological medicine(CBM)、中国知网、万方、维普数据库从建库到2016年5月的文献,对所纳入的病例-对照研究,运用Rev Man4.2软件进行Meta分析。结果:共纳入14篇病例对照研究,关于GSTM1基因缺失型与不育症关系的研究总共纳入病例组3404人、对照组2308人,关于GSTT1基因缺失型与不育症关系的研究总共纳入病例组3143人、对照组2017人。Meta分析显示:(1)亚洲人群中GSTM1缺失基因型与原发性男性不育症易感性相关性有统计学意义(OR=1.30,95%CI=1.01~1.66,P<0.05);亚组分析,东亚人群(OR=1.08,95%CI=0.94~1.23,P=0.26>0.05)、南亚人群(OR=1.06,95%CI=0.52~2.18,P=0.87>0.05)的GSTM1缺失基因型均与原发性男性不育症易感性相关性无统计学意义;而西亚人群(OR=2.01,95%CI=1.64~2.67,P=0.0001<0.05)的GSTM1缺失基因型与原发性男性不育症易感性有显著统计学意义;2、亚洲人群中GSTT1缺失基因型与原发性男性不育症易感性相关性无统计学意义(OR=1.20,95%CI=0.93~1.54,P>0.05)。亚分组分析:东亚人群(OR=1.13,95%CI=0.89~1.44,P=0.33>0.05)和西亚人群(OR=1.65,95%CI=0.98~2.77,P=0.06>0.05)中GSTT1缺失基因型均与原发性男性不育症易感性相关性无统计学意义。结论:亚洲人群中GSTM1缺失基因型可能增加原发性男性不育症易感性;亚洲人群中GSTT1缺失基因型与原发男性不育症未见相关性。

Objectives：To explore the relationship between the glutathione S-transferase gene polymorphism（GSTM1 and GSTT1） and the Asian male idiopathic infertility.Methods：Related literature published in Pub Med,Science Direct,Springer,China Biological Medicine（CBM）,China National Knowledge Infrastructure（CNKI）,Wanfang,Weipu and other databases up to December 2015 were searched,and case-control studies were included for meta-analysis by using Rev Man 4.2 software.Results：14 case-control studies were included in the study,including a total of 3404 idiopathic infertility males and 2308 controls on GSTM1 polymorphism and a total of 3143 idiopathic infertility males and 2017 controls on GSTT1 polymorphism.According to meta-analysis,GSTM1 null genotype in Asian was significantly associated with an increased risk of male idiopathic infertility（OR= 1.30,95% CI = 1.01 ~ 1.66,P = 0.04 〈 0.05）.In terms of the sub-groups,the east Asian people（OR =1.08,95% CI = 0.94 ~ 1.23,P = 0.26 〉 0.05） and the south Asian people（OR = 1.06,95% CI = 0.52 ~2.18,P = 0.87 〉 0.05） lack of GSTM1 genotypes were not significantly susceptible to primary male infertility,but the west Asian was significantly susceptible（OR = 2.01,95% CI = 1.64 ~ 2.67,P = 0.0001 〈 0.05）.2.GSTT1 null genotype in Asian was insignificantly associated with an increased risk of male idiopathic infertility（OR =1.20,95% CI = 0.93 ~ 1.54,P = 0.16 〉 0.05）.In terms of the sub-groups,the east and west Asian people lack of GSTM1 genotypes were not significantly susceptible to primary male infertility（OR = 1.13,95% CI = 0.89~ 1.44,P = 0.33 〉 0.05;OR = 1.65,95% CI = 0.98 ~ 2.77,P = 0.06 〉 0.05）.Conclusion：GSTM1 nullgenotype in Asian is significantly associated with an increased risk of male idiopathic infertility while the GSTT1 is not on the whole.