结核感染T细胞检测在肺外结核诊断中的临床意义

Clinical significance of T - SPOT. TB in the diagnosis of pulmonary tuberculosis

目的探讨结核感染T细胞检测在肺外结核诊断中的临床意义。方法选取41例肺外结核患者作为研究组，另选取41例同期体检健康者作为对照组。两组研究对象均抽取5ml外周静脉血进行结核感染T细胞检测。结果研究组结核感染T细胞检测的阳性率（95．12％）高于对照组（0．00％），差异有统计学意义（P〈0．05）。结核感染T细胞检测敏感度为95．12％（39／41），特异度为100．00％（41／41），准确度为97．56％（80／82）。经结核感染T细胞检测，支气管结核敏感度为100．00％（3／3），结核性腹膜炎敏感度为100．00％（6／6），腰椎结核敏感度为88．89％（8／9），结核性胸膜炎敏感度为100．00％（10／10），淋巴结核敏感度为92．31％（12／13），各疾病类型敏感度比较差异未见统计学意义（P〉0．05）。结论采用结核感染T细胞检测对肺外结核进行诊断具有较高的敏感度与特异度，可有效判断是否发生肺外结核感染，且能为疾病类型鉴别提供一定的参考依据。

Objective To investigate the clinical significance of T-SPOT. TB in the diagnosis of pulmonary tuberculosis. Methods Forty-one pulmonary tuberculosis patients were selected as the study group, and 41 healthy persons at the same period were selected as the control group. Five ml peripheral venous blood was extracted for T-SPOT. TB. Results The positive rate of the study group （95.12%） was higher than that of the control group （0%）, the difference was significant （ P 〈 0. 05 ）. The sensitivity of T-SPOT. TB was 95.12% （39/41）, and the specificity was 100% （41/41）, and the accuracy was 97.56% （80/82）. After testing, the sensitivity of bronchial tuberculosis, tuberculous peritonitis, lumbar tuberculosis, tuberculous pleurisy and lymphoid tuberculosis was 100% （3/3）, 100% （6/6）, 88.89% （8/9）, 100% （10/10） and 92. 31% （12/13）, respectively, there was no significant difference in the sensitivity of each disease type （P 〉 0. 05 ）. Conclusions T-SPOT. TB has high sensitivity and specificity in the diagnosis of extrapulmonary tuberculosis, which not only can effectively determine whether the occurrence of tuberculosis infection, but also can provide reference for the identification of disease types.