不同抗病毒治疗方案治疗慢性乙型肝炎的疗效观察

Comparison of therapeutic effects of different antiviral regimens on patients with chronic hepatitis B

目的探讨不同抗病毒治疗方案治疗慢性乙型肝炎的临床疗效。方法将150例慢性乙型肝炎患者随机分为三组，恩替卡韦组患者给予恩替卡韦治疗，拉米夫定组患者给予拉米夫定治疗，联合组患者给予恩替卡韦＋拉米夫定联合治疗。比较三组患者治疗前后相关疾病参数值、临床指标与并发症。结果联合组患者治疗后ALT、TBil、HBV—DNA水平与并发症发生率均低于恩替卡韦组与拉米夫定组，PTA水平、肝功复常率、HBV．NDA转阴率与HBeAg转阴率高于恩替卡韦组与拉米夫定组，差异有统计学意义（P〈0．01）。结论恩替卡韦联合拉米夫定治疗慢性乙型肝炎的临床疗效显著，具有借鉴意义。

Objective To investigate the clinical efficacy of different antiviral regimens on chronic hepatitis B （CHB）. Methods One hundred and fifty patients with chronic hepatitis B were ran- domized into three groups. Entecavir was given to patients in the enteeavir group, lamivudine was given in the lamivudine group, entecavir and lamivudine was given in the combination group. The clinical parameters and complications were compared among the three groups before and after treatment. Results The levels of ALT, TBil, HBV-DNA and complication incidences in the combination group were significantly lower than those in the entecavir group and lamivudine group; The PTA levels, liver function recovery rates, negative rates of HBV-NDA and HBeAg group were significantly higher than those of entecavir group and lamivudine group （P 〈 0.01 ）. Conclusions The efficacy of entecavir combined with lamivu- dine on chronic hepatitis B is significant and can be used for reference.