宫内或环境中的邻苯二甲酸酯对6岁儿童的性激素水平及生殖发育的影响

The Effect of Phthalates in Uterus or Environment on Sex Hormone Level and Reproductive Development of Children at 6 Years Old

邻苯二甲酸酯的抗雄激素作用可能影响暴露儿童的生殖发育。因此我们研究了宫内或环境暴露邻苯二甲酸酯的6岁儿童的生殖发育情况。我们招募了120位川东北地区2010年出生的儿童,并跟踪调查至2016年直至这些儿童年满6周岁。我们收集整理了每位儿童的出生结局,测定其骨龄、激素水平及邻苯二甲酸酯的代谢产物(邻苯二甲酸单酯(MEHP),邻苯二甲酸单丁酯(Mn BP))的水平,并评估了这些儿童的生殖发育情况。母亲尿液中邻苯二甲酸酯类代谢产物的水平与6岁儿童出生时的情况、生理特征及生殖激素的水平并不明显相关。而6岁儿童尿液中邻苯二甲酸酯类代谢产物MEHP与血清中黄体酮的水平显著相关,尤其是女孩尿液中MEHP的水平。所有儿童Mn BP的水平与血清FSH的水平显著相关。尿液邻苯二甲酸酯类代谢产物的水平与6岁儿童的生长及生殖器官的发育并不相关。因此,环境暴露邻苯二甲酸酯可能会影响儿童生殖激素的水平。邻苯二甲酸酯的环境健康效应还有待进一步研究。

The anti-androgenic effect of phthalates may affect the reproductive development of children exposed to it. Therefore, we studied the reproductive development of children at 6 years old who were exposed to phthalates in uterus or environment. 120 children born in 2010 from the northeast of Sichuan province were recruited and followed up to 2016 until they were 6 years old. Their birth outcomes were collected. Also, their bone age, hormone levels, phthalate metabolites （mono-2-ethylhexyl phthalate （MEHP） and mono-n-butyl phthalate （MnBP）） concentrations were measured. Moreover, the reproductive development of these children were assessed. There was no significant correlation between maternal urinary concentrations of phthalate metabolites and 6 years-old children＇s birth outcome, physical characteristics, and sex hormone levels. While the phthalate metabolites MEHP in 6-years-old children＇s urine correlated significantly with serum progesterone, especially that in girls＇urine. The MnBP level in all children correlated significantly with serum FSH levels. There was no significant correlation between urinary concentrations of phthalate metabolites and children＇s growth and development of reproductive organs. Taken together, we found that phthalate in environment might affect children＇s sex hormone levels. The environmental health effects ofphthalate needs further research.