乙酰半胱氨酸对特发性间质性肺炎患者血气分析的影响

Effect of Acetylcysteine on Blood Gas Analysis in Patients with Idiopathic Interstitial Pneumonia

本研究将88例特发性间质性肺炎患者根据随机数字表分为两组,其中对照组予以强的松+硫唑嘌呤治疗,观察组予以强的松+硫唑嘌呤+乙酰半胱氨酸治疗。对比两组治疗前后的疗效及患者Pa O_2、Pa CO_2、FVC、DLCO/VA、FEV1、VC、TLC的水平变化,发现观察组有效率高于对照组,差异有统计学意义(p<0.05);两组治疗前的动脉血气水平差异无统计学意义(p>0.05);治疗后的动脉血气水平较治疗前明显改善,观察组的改善程度较对照组明显(p<0.05)。两组治疗前的VC、FEV1、FVC、TLC、DLCO/VA差异无统计学意义(p>0.05);治疗后的VC、FEV1、FVC、TLC、DLCO/VA较治疗前提高,且观察组比对照组变化明显(p<0.05)。提示糖皮质激素、硫唑嘌呤联合乙酰半胱氨酸治疗特发性间质性肺炎效果显著,可改善机体肺纤维化,值得推广。

In this study, according to the random number table, 88 cases of idiopathic interstitial pneumonia patients were divided into two groups. Control group were treated by corticosteroids and azathioprine while observation group were treated by corticosteroids, azathioprine and acetylcysteine. After contrasting the curative effect of two groups, and also their level changes of PaO2, PaCO2, FVC, DLCO/VA, FEV1, VC, TLC before and after treatment, we found that the effective rate of observation group was obviously higher than that of control group, of which difference was statistically significant （p〈0.05）. There were no significant differences between two groups of arterial blood gas level before treatment （p〉0.05）. The blood gas levels after treatment were better than those before treatment, and the change of the observation group was more obvious than the control group （p〈0.05）. There were no significant differences between two groups ofFVC, DLCOFVA, FEV1, VC, TLC levels before treat- ment （p〉0.05）. FVC, DLCONA, FEV1, VC, TLC levels after treatment were better than those of before treatment, and the change of observation group was more obvious than control group （p〈0.05）. In conclusion, corticosteroids, azathioprine joint acetylcysteine treatment of idiopathic interstitial pneumonia clinical effect was remarkable. This method could improve pulmonary fibrosis, which was worthy of being recommended.