摘要
目的探讨HPV16/18型病毒检测与宫颈癌的相关性。方法选取宝鸡市中心医院2011-2014年收治的宫颈鳞癌患者100例作为宫颈癌组,并选取同期在该院体检中心接受体检的健康受试者100例作为对照组,分别取两组受试者的宫颈分泌物,提取DNA,通过q PCR技术对HPV16/18 DNA的载量进行测定,比较两组受试者的检测阳性率。结果宫颈癌患者和健康受试者的HPV16/18 DNA载量相对值分别为(7.77±4.05)和(4.50±3.05),阳性率分别为77.00%和27.00%,宫颈癌患者显著高于健康受试者,经比较差异有统计学意义(P<0.05)。结论宫颈鳞癌与HPV16/18型病毒感染之间存在显著相关性,通过早发现、早期疗,做好对高危人群的筛查是宫颈癌防治的重要方法。
Objective To explore the correlation between HPV16/18 detection and cervical cancer. Methods A total of 100 patients with cervical cancer were selected as cervical cancer group from the hospital from 2011 to 2014,and 100 healthy subjects receiving physical examination in physical examination center of the hospital were selected as control group. The cervical secretion samples and DNA in the two groups were extracted respectively. HPV16/18 DNA load was measured by q PCR technique,and positive rates in the two groups were compared. Results The relative values of HPV16/18 DNA load in cervical cancer patients and healthy subjects were（ 7. 77 ± 4. 05） and（ 4. 50±3. 05）,respectively,and the positive rates were 77. 07% and 27. 27%,respectively. The relative value of HPV16/18 DNA load and positive rate in patients with cervical cancer were statistically significantly higher than those in healthy subjects（ P 0. 05）.Conclusion There is a significant correlation between cervical squamous cell carcinoma and HPV 16/18 infection. It is an important method to prevent and treat cervical cancer through early detection,early treatment and good screening for high-risk population.
出处
《中国妇幼保健》
CAS
2017年第16期3725-3727,共3页
Maternal and Child Health Care of China
基金
宝鸡市卫生和计划生育局科研课题(2015-02)
