小儿尿道下裂尿道板组织中雌激素受体及微血管密度的表达及临床意义

Expressions and Clinical Significances of Estrogen Receptor and Microvessel Density in Urethral Plate Tissues of Children with Hypospadias

目的探讨尿道下裂患儿尿道板组织和尿道部皮肤组织中雌激素受体(ER)和微血管密度(MVD)的表达及意义。方法选取2013年6月—2015年1月天津儿童医院收治的尿道下裂手术患儿30例,术中分别取部分尿道板和尿道部皮肤组织,检测不同组织中ER及MVD的表达及分布情况。结果 2组均检测到ER及MVD的表达。尿道板组织与尿道部皮肤组织中ER表达水平比较差异无统计学意义(P>0.05),尿道板组织中MVD低于尿道部皮肤组织(P<0.05)。结论尿道板组织和尿道部皮肤组织ER含量接近,可能与尿道发育异常有关;尿道板组织中存在微血管分布,为保留尿道板的尿道成形术提供了理论依据;尿道板组织内MVD显著降低,可能为术后发生尿瘘的原因之一。

Objective To investigate expressions and clinical significances of estrogen receptor （ER） and microvessel density （MVD） in urethral plate tissues of children with hypospadias. Methods A total of 30 children with hypospadias admitted during June 2013 and January 2015 underwent surgical treatments. Part urethral plate tissues and urethral skins were collected during the surgery, and expressions and distributions of ER and MVD in different tissues were detected. Results Expressions of ER and MVD were detected in both groups. There were no significant differences in ER expressions between urethral plate tissues and urethral skin tissues （P 〉 0. 05）. MVD expressions in urethral plate tissues were significantly lower than those in urethral skin tissues （P 〈 0. 05 ）. Conclusion ER expressions in urethral plate tissues and urethral skins are similar, which may be correlated with urethral abnormality of development. MVD distribution can be found in urethral plate tissues, which provides basis for retaining urethral plate in urethroplasty. MVD expressions are significantly decreased in urethral plate tissues, which may be one of causes of having postoperative urinary fistula.