玉屏风散对肺气虚证大鼠血液流变学的影响

Effect of Yupingfeng powder on hemorheology of rats with Lung-Qi deficiency

目的:观察玉屏风散对肺气虚证大鼠的血液流变学的影响。方法:48只SD大鼠随机分为正常对照组、肺气虚模型组、玉屏风散高剂量组和玉屏风散低剂量组。正常对照组则于无烟环境中饲养。其余各组采用改良烟熏法,复制肺气虚证SD大鼠模型。于造模开始第1天起,正常对照组和肺气虚模型组均进行每日1次的生理盐水灌胃,玉屏风散高剂量组、低剂量组用药剂量为4.8 g/kg、2.4 g/kg,每日1次灌胃,持续灌胃30 d。30 d后取大鼠腹主动脉血,进行血液流变学检测。结果:与正常对照组相比,模型组大鼠的Fib、HCT、ηb、ηh、ηp升高,VAL和TEL增大,MST延长;与模型组比较,玉屏风散高剂量组Fib、ηb、ηh明显降低,VAL和TEL减小,MST显著缩短。结论:玉屏风散能显著改善肺气虚证大鼠血液流变学异常。

Objective：To investigate the effect of Yupingfeng powder on hemorheology of rats with Lung-Qi deficiency. Method：48 rats were randomly divided into normal control group, model group, the high dose group of Yupingfeng powder and the low dose group of Yupingfeng powder. Except normal control group,the other groups were replicated the models of rats with Lung-Qi deficiency through modified smoke inhalation. At the start of the model from the first day, the normal control group and lung qi deficiency model groups were given with saline,Yupingfeng po^vder high,low dose groups were given Yupingfeng powder with 4.8 g/kg,2.4 g/kg, 1 times per day,continuous administration of 30 d. The blood of abdominal aorta is obtained in thirty days for the test of hemorheology. Result： Compared with the normal control group,Fib, HCT, ηb,ηh,ηp, VAL and TEL increased, MST of model group rats was increased.Compared with the model group, Fib,ηb,ηh, VAL and TEL of Yupingfeng powder high dose group were decreased,MST was significantly shortened. Conclusion： Yupingfeng powder has significant improvement in treatment of hemorheology of rats with Lung-Qi deficiency.