全肺灌洗治疗肺泡蛋白沉积症18例分析

Analysis of 18 Cases of Pulmonary Alveolar Proteinosis treated with Whole Lung Lavage

目的观察大容量全肺灌洗治疗肺泡蛋白沉积症病例的疗效。方法回顾性研究大容量全肺灌洗治疗肺泡蛋白沉积症病例18例,通过对患者临床资料的分析,研究肺泡蛋白沉积症确切有效的治疗方法。结果术中并发症灌洗液外漏3例,低氧血症2例,心律失常2例,均及时采取处理措施,未发生不良后果。实验室结果显示,患者经全肺灌洗后,临床症状缓解,肺功能,血气分析指标均有明显改善,差异有统计学意义。结论全肺灌洗术可将肺泡蛋白沉积症患者肺泡、细支气管内类蛋白物质洗出,安全性高,不良反应发生率低,是有效的治疗方法。

Objectlve To observe the effect of large volume whole lung lavage in the treatment of pulmonary alveolar proteinosis. Methods A retrospective study of 18 patients with pulmonary alveolar proteinosis treated with large volume whole lung lavage was performed to analyze the clinical data of the patients. Results There were 3 eases of intraoperative fluid leakage, hypoxemia in 2 cases, arrhythmia in 2 eases. All of them were treated in time. The results showed that the clinical symptoms, pulmonary function and blood gas analysis index were improved significantly after the whole lung lavage. Conclusion Whole lung lavage can make the protein material washout and alveolar pulmonary alveolar proteinosis in bronchiole, high safety, low incidence of adverse reactions, which is an effective treatment method.