皮肤屏障功能异常与银屑病

Skin Barrier Dysfunction and Psoriasis

人的皮肤具有屏障功能,它在保护皮肤抵御外界刺激及保持皮肤微环境的稳态中起到重要作用。银屑病是一种通过表皮角化细胞和免疫细胞的相互作用引起的慢性炎症性皮肤病,目前其发病机理尚不明确。最近的研究揭示了表皮屏障相关基因的缺陷与银屑病的风险相关。越来越多的研究表明,皮肤屏障功能的异常,与银屑病的发病有着密切的关系,可能是银屑病发病的主要诱因之一。

Human skin has a barrier function, which plays an important role in protecting skin from external stimuli and maintaining the stable state of the skin microenvironment. Psoriasis is an inflammatory skin disease, which develops through the interaction of epidermal keratinocytes and immune cells, although its pathoetiology has not been fully understood. Recent studies revealed that defects in epidermal barrier-related genes were associated with a risk of psoriasis. More and more studies have shown that abnor- mal skin barrier function is closely related to the incidence of psoriasis which may be one of the main incentives of this diease.