冻融胚胎移植周期临床结局的影响因素

Influence factors of clinical outcomes of frozen-thawed embryo transfer

目的:探讨玻璃化冷冻胚胎复苏移植临床结局的影响因素。方法:回顾性分析2 430个冻融胚胎移植周期,研究患者年龄、授精方式、内膜厚度、胚胎冷冻保存时间、胚胎在平衡液中的平衡时间和胚胎质量对冻融周期胚胎移植结局的影响。结果与结论:年龄(β=-1.029,P<0.001)、胚胎冷冻保存时间(β=-0.101,P<0.05)和胚胎质量(D3胚胎和D5/D6囊胚质量的β分别为-2.824和-2.878,P<0.001)是冻融胚胎移植临床妊娠率的主要影响因素。

Aim：To explore the influence factors of the frozen thawed embryo transfer（FET） outcomes of human vitrified embryos.Methods： A total of 2 430 FET cycles were collected,and the effects of the age of the patients,insemination ways,endometrium thickness,embryo cryopreservation time,the balance time of embryos in equilibrium liquid and the quality of embryo on the clinical outcomes were analyzed.Results and conclusion： The results showed that age（β=-0.101,P〈0.001）,embryo cryopreservation time（β=-0.101,P〈0.05）and embryo quality（D3 β=-2.824,D5YD6 β=-2.878,P〈0.001） were the influence factors of clinical pregnancy rate.