内脂素、网膜素与妊娠期高血压疾病关系的研究进展

Research progress of relationship between visfatin and omentin and hypertensive disorder complicating pregnancy

妊娠期高血压疾病(HDCP)是妊娠期特有的疾病,可造成孕产妇子痫发作,产时、产后出血,胎儿窘迫,甚至死亡,对母婴危害极大。脂肪组织是脂质储存的场所,可分泌脂肪细胞因子如肿瘤坏死因子(TNF)、白细胞介素(IL)、瘦素等,参与调节糖脂代谢及炎症反应。内脂素(visfatin)和网膜素(omentin)是近几年新发现的脂肪细胞因子,文献报道其可能对HDCP的发生、发展产生影响,但结论并未统一。

Hypertensive disorder complicating pregnancy（ HDCP） is a pregnancy-specific disease. It can cause maternal epilepsy,postpartum hemorrhage,fetal distress,and even death. It＇s very harmful to mother and infant. Adipose tissue is a place of lipid storage,and can secrete adipocytokines such as tumor necrosis factor（ TNF）,interleukin（ IL）,leptin and so on. These adipocytokines participate in the regulation of metabolism and inflammatory. Visfatin and omentin are newly discovered cytokines in recent years. It is reported that they can have an impact on the occurrence and development of HDCP,but the conclusion is not unified.