肠道菌群失调——非酒精性脂肪肝病治疗新靶点

Imbalance of intestinal flora:A new target for nonalcoholic fatty liver disease treatment

非酒精性脂肪肝病(non-alcoholic fatty liver disease,NAFLD)是一种除饮酒以及其他肝损害因素外所致的以肝实质细胞脂肪变性及贮积为特征的临床病理综合征.近年来,随着人们生活方式的改变,NAFLD已成为全球公共健康问题,其发生率与肥胖、2型糖尿病等代谢综合征相关.越来越多文献表明肠道菌群与NAFLD的发生发展关系密切:(1)肠道菌群失调可促进宿主吸收更多的能量;(2)肠道菌群失调可诱导机体脂质代谢紊乱,肝细胞脂质蓄积;(3)肠道菌群失调可增加肠黏膜通透性、促发炎症.因此,本文就肠道菌群与NAFLD关系进行整理,为寻找治疗NAFLD的药物提供新靶点进行简要综述.

Non-alcoholic fatty liver disease（NAFLD） is a clinical pathologic syndrome characterized by steatosis and storage of hepatic parenchymal cells due to liver damage caused by factors other than alcohol. In recent years, with the change of people＇s lifestyle, NAFLD has become a global public health problem. The incidence of NAFLD is associated with obesity,type-2 diabetes and other metabolic syndromes.More and more studies indicate that intestinal flora is closely related with the occurrence and development of NAFLD：（1） Intestinal flora can promote the energy metabolism of the host;（2） Intestinal flora can induce the body lipid metabolism disorders and liver cell lipid accumulation; and（3） Intestinal flora can increase the intestinal mucosal permeability and activate inflammation. This article summarizes the relationship between NAFLD and intestinal flora imbalance, which may be a new target for NAFLD treatment.