艾瑞昔布单独应用及与仙灵骨葆胶囊联合治疗膝骨关节炎的疗效比较

Comparison study on effect of imrecoxib applied alone and combined with xianlinggubao for the treatment of knee osteoarthritis

目的:通过对患者治疗前后症状的缓解、功能的改善等方面进行综合比较,探讨艾瑞昔布单独应用及与仙灵骨葆胶囊联合治疗早中期膝骨关节炎(Knee Osteoarthritis,KOA)疗效,为临床防治KOA提供新方法。方法:收集2015年6月~2016年5月光华、同仁医院门诊的KOA患者作为研究对象,最终纳入126例KOA病例,根据患者自愿原则分为艾瑞昔布单独应用组和与仙灵骨葆胶囊联合应用组,作临床对比研究。应用SPSS17.0统计软件对所有数据进行统计学分析后得出客观的结果和结论。结果:研究中两组共计脱落病例19例,最终126例KOA患者进入结果分析。WOMAC评分,治疗后第2、4、8周两组评分标准指数比较差异具有统计学意义(P<0.05),联合用药组患者的综合评分指数明显低于艾瑞昔布组。结论:艾瑞昔布是一种较为理想的治疗早中期KOA的非甾体抗炎药,其疗效确切。仙灵骨葆胶囊可作为治疗早中期KOA的辅助用药,无明显毒副作用。中西两药合用不良反应小,能有效缓解KOA的临床症状、改善膝关节功能和提高生活质量。

Objective： To investigate the effect of Imrecoxib applied alone and combined with Xianlinggubao capsule for the treatment of early and middle stage KOA through a comprehensive comparison of the relief of patients symptoms,the functional improvement of knee joint after treatment,providing a new method for the prevention and treatment of KOA in clinical. Methods： Collecting the treated cases of KOA as the research objects from June 2015 to May 2016 in outpatient of Guanghua hospital and Tongren hospital,126 patients of KOA were included in research,according to the principle of voluntary patients were divided into Imrecoxib group and combination group,then done a study of clinical comparative test. Using SPSS17. 0 statistical software processed all data and got the objective results and conclusions through analysis. Results： In the study,a total of 19 cases dropped,126 patients of KOA got into the result analysis finally. In terms of WOMAC rating scale,after the treatment of 2^（nd）,4^（th） and 8^（th） week,the difference of standard index between two groups was statistically significant（ P〈0. 05）. Conclusions： Imrecoxib is a comparatively ideal non-steroidal anti-inflammatory drug for the treatment of early and middle stage KOA,and the efficiency is reliable. Xianlinggubao capsule can be used as adjuvant therapy in the treatment of early and middle stage KOA,it has no obvious toxic side effect. Combined application of traditional Chinese medicine and Western medicine has less adverse reactions,can effectively relieve the clinical symptoms of KOA,improve the function of knee joint and enhance the quality of life.