舒肝解郁胶囊合并草酸艾司西酞普兰对抑郁症患者焦虑、抑郁状态疗效临床研究

The efficacy of Shuganjieyu Capsules combined escitalopramin on anxiety and depression symptoms in depression patients

目的探讨舒肝解郁胶囊合并草酸艾司西酞普兰对抑郁症患者的效果。方法 2015年5月~2016年12月在我院门诊就诊的抑郁症患者50人,依照给药方式不同分为试验组25例与对照组25例。对照组给予草酸艾司西酞普兰10mg/次口服,1d/次。试验组:给予草酸艾司西酞普兰10mg/次口服,1d/次,同时加服舒肝解郁胶囊,2粒/次,2次/d,早晚各1次,两组疗程均为6周。用焦虑自评量表SAS、抑郁自评量表SDS作为评价焦虑抑郁状态程度,用日常生活能力评定表(ADL)为患者评估日常生活能力。并观察记录服药期间出现的不良反应。结果治疗后试验组和对照组的SAS和SDS评分均有明显下降。试验组在治疗4周、6周后其SAS、SDS均低于对照组(P<0.05);两组患者在治疗4周、6周后日常生活能力评分均低于治疗前,且试验组治疗6周的评分优于对照组,差异有统计学意义(P<0.05)。用药期间两组不良反应发生率无统计学差异(P>0.05)。两组用药后均无血、尿常规、肝、肾功能无明显变化。结论舒肝解郁胶囊合并草酸艾司西酞普兰可更好的改善抑郁症患者的抑郁、焦虑症状和日常生活能力,安全性好。

Objective To observe the clinical efficacy of Shuganjieyu Capsules combined escitalopram in depression patients. Methods 50 depression patients were divided into experimental group（n=25）and control group（n=25）. The control group was given escitalopram（10 mg/time,1d/time）. Experimental group was given escitalopram（10mg/time,1d/time）and Shuganjieyu capsules（2 grain/time,2 time/d）,the duration of treatment was 6weeks. The SAS and SDS were applied to evaluate the degree of anxiety and depression,and the ADL was use to evaluate daily life ability of patients. All of adverse reactions during the treatment were recorded. Results Compared with before treatment,the scores of SAS,SDS and ADL in both two groups were lower than those after treatment. After 6weeks of treatment,the scores of SAS,SDS and ADL in experimental group were lower than those in control group（P〈0.05）. The number of adverse reactions in two groups was no different. Conclusion Shuganjieyu capsules combined escitalopram can improve the depression,anxiety and daily life ability in patients with depression.