丁苯酞氯化钠注射液用于脑梗死患者治疗对脑梗死后抑郁的预防效果评价

The effect of butylphthalide and sodium chloride injection on depression in patients after cerebral infarction

目的探究丁苯酞氯化钠注射液对脑梗死后抑郁患者的预防效果。方法选取2015.12~2016.6之间河北大学附属医院收治的60例急性脑梗死患者,数字表法随机分组,对照组30例进行常规治疗,研究组30例在此基础上应用丁苯酞氯化钠注射液治疗,两组患者均连续治疗14d,采用美国国立卫生研究院卒中量表(NIHSS)评价神经功能缺损状况,并采用汉密尔顿抑郁量表(HAMD)评价抑郁表现情况。结果治疗后两组患者的NIHSS评分均显著改善,但研究组改善程度显著优于对照组(P<0.05);治疗后两组患者的HAMD评分均显著改善,但研究组改善程度显著优于对照组(P<0.05)。结论丁苯酞氯化钠注射液能够有效改善脑梗死患者的神经功能缺损,同时可减少脑梗死后抑郁的发生。

Objective To investigate the effect of butylphthalide and sodium chloride injection on depression in patients after cerebral infarction. Methods 60 patients with acute cerebral infarction were randomly divided into study group and control group（n = 30）. The patients in the two groups were treated with routine therapy. The study group were treated by butylphthalide and sodium chloride injection. The NIH Stroke Scale（NIHSS）was used to evaluate the neurological deficits of patients in two groups The Hamilton Depression Scale（HAMD）was used to evaluate the depression in two groups. Results There was no significant difference in NIHSS and HAMD score between the two groups before treatment（P〈0.05）. After treatment,the NIHSS and HAMD score in the study groups was significantly lower than that in the control group,the difference was statistically significant（P〈0.05）.Conclusion The butylphthalide and sodium chloride injection can effectively improve the neurological deficits of patients after cerebral infarction,and can reduce the occurrence of depression after cerebral infarction.