隐源性卒中合并卵圆孔未闭患者的抑郁和焦虑情况以及封堵术对其的影响

The change of depression and anxiety in patients with cryptogenic stroke and patent foramen ovale after the blocking operation

目的评估卵圆孔封堵术前后患者的抑郁和焦虑水平的变化。方法以2011年1月至2014年12月我院心外科接受封堵术的隐源性卒中合并卵圆孔未闭患者80例为研究对象。采用Znug抑郁自评量表(SDS)和Znug焦虑自评量表(SAS)评估手术前后的患者的抑郁和焦虑水平。结果一共有80例患者完成了SDS和SAS的评估。患者的抑郁症和焦虑症的严重程度在手术后明显下降(P<0.001)。SDS和SAS术前总分高是术后改善的独立预测因素(P<0.001)。女性患者的术前SDS评分明显较差(P=0.005)但是术后改善更明显(P=0.012)。结论抑郁和焦虑是隐源性卒中合并卵圆孔未闭的患者人群中普遍存在的心理问题,而封堵术能有效地改善抑郁症和焦虑症状。

Objective To investigate the changes of depression and anxiety in patients with cryptogenic stroke and patent foramen ovale（PFO）after the blocking operation. Methods From January 2011 to December 2014,80 patients with cryptogenic stroke and PFO were enrolled. The depression and anxiety levels before and after surgery were assessed by the Zung Depression Rating Scale（SDS）and the Zung Anxiety Rating Scale（SAS）. Results The severity of depression and anxiety was significantly reduced after surgery;the mean scores of SDS and SAS decreased from moderate to normal（P〈0.001）. SDS and SAS were the independent predictors of postoperative improvement（P〈0.001）. Female patients had a significantly lower preoperative SDS score（P =0.005）but had more significantly improvement postoperative（P=0.012）. Conclusion Depression and anxiety are common problems in patients with cryptogenic stroke and PFO,and blocking operation can effectively improve depression and anxiety symptoms.