非甾体抗炎药对伴有幽门螺杆菌感染风湿病患者胃肠激素及消化道的影响

Influence of nonsteroidal anti-inflammatory drugs on gastrointestinal hormones and adverse digestive tract situation of rheumatic disease patients complicated with Helicobacterpyloriinfection

目的研究及观察非甾体抗炎药对伴有幽门螺杆菌感染风湿病患者胃肠激素及不良消化道情况的影响,以了解幽门螺杆菌感染对该类患者消化系统的危害。方法选取2015年5月-2016年4月医院诊治的38例伴有幽门螺杆菌感染的风湿病患者为观察组,选取同时间段的35例无幽门螺杆菌感染的风湿病患者为对照组,对两组患者不良消化道情况发生率,治疗前后不同时间的血清胃肠激素水平进行前瞻性研究及比较。结果观察组十二指肠溃疡、胃溃疡及糜烂性胃炎发生率为18.42%、13.16%、13.16%,均高于对照组的2.86%、0、0(P<0.05);治疗前两组患者的餐前及餐后血清胃肠激素水平均无明显差异,治疗后不同时间观察组的餐前及餐后血清胃肠激素GAS、MTL、VIP及CKK水平分别为(102.52±10.47)ng/L、(229.89±21.65)ng/L、(120.75±11.01)ng/L、(14.88±1.49)pg/ml,(110.23±11.35)ng/L、(268.48±25.95)ng/L、(137.37±12.54)ng/L、(12.58±1.32)pg/ml;(108.69±12.56)ng/L、(248.58±22.97)ng/L、(130.17±12.84)ng/L、(16.32±1.68)pg/ml,(123.56±14.68)ng/L、(283.93±26.75)ng/L、(140.77±13.92)ng/L、(14.93±1.52)pg/ml,均高于对照组(P<0.05)。结论:非甾体抗炎药物对伴有幽门螺杆菌感染风湿病患者胃肠激素及不良消化道情况的影响较大,应对该类患者进行积极的抗幽门螺杆菌治疗。

OBJECTIVE To explore the influence of nonsteroidal anti-inflammatory drugs on gastrointestinal hormones and adverse digestive tract situation of rheumatic disease patients complicated with Helicobacter pylori infection so as to understand the harm of H.pylori infection on digestive system of the patients.METHODS A total of 38 rheumatic disease patients complicated with H.pylori infection who were treated in the hospital from May 2015 to Apr 2016 were chosen as the observation group, meanwhile, 35 rheumatic disease patients without H.pylori infection were set as the control group.The incidence of adverse digestive tract situation was observed and compared between the two groups of patients, and the levels of serum gastrointestinal hormones were prospectively studied and compared before and after the treatment for different time periods.RESULTS The incidence rates of duodenal ulcer, gastric ulcer and erosive gastritis of the observation group were respectively 18.42%, 13.16% and 13.16%, higher than 2.86%, 0 and 0 of the control group （all P＆lt;0.05）;there was no significant difference in the levels of serum gastrointestinal hormones between the two groups of patients before the treatment （before and after meals）.The levels of serum gastrointestinal hormones GAS, MTL, VIP and CKK of the observation group were respectively （102.52±10.47）ng/L,（229.89±21.65）ng/L,（120.75±11.01）ng/L,（14.88±1.49）pg/ml,（110.23±11.35）ng/L, （268.48±25.95）ng/L, （137.37±12.54）ng/L, （12.58±1.32）pg/ml and（108.69±12.56）ng/L, （248.58±22.97）ng/L, （130.17±12.84）ng/L,（16.32±1.68）pg/ml, （123.56±14.68）ng/L,（283.93±26.75）ng/L, （140.77±13.92）ng/L, and（14.93±1.52）pg/ml before and after meals （after the treatment for different time periods）, higher than those of the control group （all P〈0.05）.CONCLUSION The nonsteroidal anti-inflammatory drugs may have great impact on the gastrointestinal hormones and adverse digestive tract situation of rheumatic disease patients complicated with H.pylori infection, and it is necessary to actively conduct the anti-H.pylori treatment for this group of patients.