宫颈癌患者人乳头瘤病毒与巨细胞病毒和单纯疱疹病毒Ⅱ型感染的相关性研究

Correlation between cervical carcinoma and human papillomavirus,cytomegalovirus and herpes simplex virus type II infection

目的探讨宫颈癌(CC)和单纯疱疹病毒Ⅱ型(HSVⅡ)、巨细胞病毒(HCMV)及16、18及35型人乳头瘤病毒(HPV)感染的关系,为CC的发病机制研究和防治工作提供科学参考。方法选取医院2013年2月-2015年2月接诊的130例宫颈疾病患者,按照患者宫颈病情不同,将64例患有良性宫颈疾病的患者归为良性组,66例CC患者归为CC组,另选取60例宫颈正常的健康女性作为对照组,比较3组HPV、HCMV、HSVⅡ检出率。结果对照组未检测出HPV 16、HPV18、HPV35阳性,CC组HCMV检出率分别为77.27%、74.24%、72.73%,HSVⅡ检出率分别为74.24%、72.73%、72.73%,阳性检出率在不同检测点均显著高于对照组和良性组,差异均有统计学意义(P<0.05)。结论 HSVⅡ、HPV 16、HPV18、HCMV感染均能够提高CC发病率,其与CC的病情进展有重要关联,及早对HCMV、HSVⅡ、HPV 16、HPV18高危群体进行筛查有利于宫颈癌的诊断治疗。

OBJECTIVE To investigate the relationships between cervical carcinoma （CC） and herpes simplex virus type II （HSV II）, human cytomegalovirus （HCMV） and type 16, 18 and 35 human papilloma virus infection, so as to provide scientific references for the pathogenesis and prevention of CC.METHODS A total of 130 patients with cervical disease from Feb.2013 to Feb.2015 were retrospectively chosen.According to the cervical disease condition of patients, they were divided into benign group （n=64） with benign cervical disease , and CC group with CC （n=66）, and another 60 normal women were selected as control group.The detection rates of HPV, HCMV, HSV Ⅱ of the three groups were compared.RESULTS HPV 16, HPV18 and HPV35 were not detected in control group.The detection rates of HCMV were 77.27%, 74.24%, and 72.73%, the detection rates of HSVⅡwere 74.24%, 72.73%, and 72.73% in CC group, which were all significantly higher than those of control group and benign group at different detection points （P〈0.05）.CONCLUSION HSV Ⅱ, HPV 16, HPV 18, and HCMV infection can increase the incidence of CC, which is closely related to the progression of CC.Early screening of HCMV, HSV Ⅱ, HPV 16, and HPV 18 high risk groups is helpful for the diagnosis and treatment of cervical cancer.