阿奇霉素治疗孕妇肺炎支原体感染的疗效观察及不良反应监测分析

Efficacy of azithromycin in treatment of Mycoplasma pneumoniae infection in pregnant women and surveillance of adverse reactions

目的探讨阿奇霉素治疗孕妇肺炎支原体感染的疗效及安全性。方法选取医院2015年7月-2016年7月医院产科收治的60例肺炎支原体感染孕妇,根据治疗方案的不同将患者分为观察组和对照组,每组各30例;所有患者入院后均配合进行相关检查,予以对症治疗,观察组在此基础上予以阿奇霉素进行治疗,对照组予以红霉素进行治疗,观察两组患者临床治疗效果、体温恢复正常时间、咳嗽咳痰好转时间、肺部啰音消失时间、不良反应及治疗后用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、FVC/FEV1、深吸气量(IC)。结果与对照组相比,观察组治疗后痊愈率53.33%及总有效率为93.33%均明显提升,差异有统计学意义(P<0.05);且观察组患者体温恢复正常时间、咳嗽咳痰好转时间、肺部啰音消失时间及住院时间均显著缩短,差异有统计学意义(P<0.05);观察组患者的轻微腹痛、恶心呕吐、注射部位疼痛及丙氨酸氨基转移酶(ALT)等不良反应率显著低于对照组,差异有统计学意义(P<0.05);观察组患者FVC、FEV1、VC/FEV1及IC均显著低于对照组,差异有统计学意义(P<0.05)。结论阿奇霉素对妊娠期妇女伴肺炎支原体感染治疗效果良好,临床症状缓解较快,不良反应较少,临床应用前景广阔。

OBJECTIVE To explore the efficacy and safety of azithromycin in treatment of Mycoplasma pneumoniae infection in pregnant women.METHODS A total of 60 pregnant women with M.pneumoniae infection who were treated in department of obstetrics from Jul 2015 to Jul 2016 were enrolled in the study and divided into the observation group and the control group according to the treatment regimens, with 30 cases in each group.All of the enrolled patients received related check-ups under coordination after the admission and were given symptomatic therapy, the observation group was treated with additional azithromycin, and the control group was treated with additional erythromycin.The clinical therapeutic effect, time of recovery of body temperature, time of improvement of cough and expectoration, time of disappearance of pulmonary rales, incidence of adverse reactions, forced vital capacity （FVC）, forced expiratory volume in one second （FEV1）, FVC/FEV1, and inspiratory capacity （IC） were observed and compared between the two groups of patients.RESULTS The cure rate of the observation group was 53.33%, significantly higher than that of the control group;the total effective rate of treatment of the observation group was 93.33%, significantly higher than that of the control group （P〈0.05）.The time of recovery of body temperature, time of improvement of cough and expectoration, time of disappearance of pulmonary rales and length of hospital stay were significantly shorter in the observation group than in the control group （P〈0.05）.The incidence of adverse reactions such as mild abdominal pain, nausea and vomiting, pain of injection sites, and alanine aminotransferase （ALT） was significantly lower in the observation group than in the control group （P〈0.05）.The FVC, FEV1, VC/FEV1 and IC of the observation group were significantly lower than those of the control group （P〈0.05）.CONCLUSION Azithromycin can achieve remarkable effect on treatment of the pregnant women with M.pneumoniae infection, it can facilitate the recovery of clinical symptoms, there are few of adverse reactions, and the clinical application has broad prospects.