ACEI类降压药物对原发性高血压病患者远期肾功能的保护作用

Protective effects of ACEA antihypertensive drugs on long-term renal functions in essential hypertension patients

目的:探讨ACEI类降压药物对原发性高血压病患者的降压和远期肾功能保护作用。方法:选取我院收治的50例原发性高血压病患者为研究对象,所有患者皆口服盐酸贝那普利进行降压治疗,剂量为10 mg/次,1次/d,疗程为12周,随访观察6个月。结果:随访结束后患者收缩压、舒张压、血β2-MG、尿β2-MG、U24pro皆显著低于治疗前,差异有统计学意义(P<0.05)。治疗前与随访结束后患者心率、Cr、BUN变化差异无统计学意义(P>0.05)。结论:ACEI类降压药物治疗原发性高血压病患者可以达到有效控制血压的目的,具有良好的肾脏保护作用,值得应用与推广。

Objective： To discuss the protective effect of ACEI antihypertensive drugs on the long-term renal functions in essential hypertension patients. Methods： 50 cases of essential hypertension patients in our hospital were selected as the subjects. All patients were treated with oral benazepril for hypotensive treatment for a treatment course of 12 weeks,with the dose of 10 mg,1 times a day,and patients had been followed-up and observed for 6 months. Results： After the follow-up,the systolic blood pressure,diastolic blood pressure,blood β2-MG,urinary β2-MG and U24 pro were significantly lower than those before treatment,which were of statistical differences（ P〈0. 05）. There were no significant differences in heart rate,Cr and BUN between the patients before treatment and after the follow-up（ P〉0. 05）. Conclusion：ACEI antihypertensive drugs in patients with essential hypertension can effectively control the blood pressure,and protect the renal functions of patients,which can be worthy of application and promotion.