术后重度脓毒血症患者检测CRP和PCT对疾病病情及预防判断效果

Effect of CRP and PCT on the prevention and prognosis in patients with severe sepsis

目的:探讨术后重度脓毒血症患者检测CRP和PCT对疾病病情和预后判定效果。方法:收集我院诊治术后重度脓毒血症患者92例临床资料行回顾性分析,根据患者预后分为A组(病情好转或治愈出院,71例)和B组(病情恶化或死亡,21例),比较两组患者治疗前及治疗1,3,7 d的CRP、PCT水平,并采用ROC曲线预测CRP和PCT与重度脓毒血症患者不良预后关系。结果:治疗前及治疗3,7 d A组患者CRP水平均低于B组(P<0.01)。治疗前及治疗1,3,7 d A组患者PCT水平均低于B组(P<0.05)。经ROC曲线分析,得出CRP、PCT在术后重度脓毒血症患者不良预后中有重要预测价值,曲线下面积在0.65~0.75。结论:CRP、PCT在术后重度脓毒血症患者中检测能对疾病严重程度和预后作出判断。

Objective： To investigate the effect of CRP and PCT detection on the disease and prognosis of patients with severe sepsis after operation. Methods： Clinical data of 92 cases of severe sepsis patients in our hospital were retrospectively analyzed. According to the prognosis of patients,they were divided into Group A（ condition improved or cured,71 cases） and Group B（ disease progressed or death,21 cases）.CRP and PCT levels of patients before treatment and 1,3 and 7 days after treatment were compared,and ROC curve was used to predict the relationship between CRP and PCT and the poor prognosis of severe sepsis patients. Results： Levels of CRP in patients of Group A before treatment and 3 and 7 d after treatment were lower than those in group B（ P〈0.01）. Before treatment and 1 d,3 d,and 7 d,level of PCT in Group A was lower than that in group B（ P〈0.05）. ROC curve analysis showed that CRP and PCT had important predictive value in the poor prognosis of patients with severe sepsis after operation. The area under the curve was between 0. 65 and 0. 75. Conclusion： CRP and PCT in patients with severe postoperative sepsis can detect the severity of the disease and determine prognosis.