中药制剂肝毒性的影响因素探析

Influence factors for hepatotoxicity of traditional Chinese medicine preparations

中药制剂作为中药发展及质量控制的重要方面,其安全性问题日益突出。肝脏作为人体最主要的药物代谢器官,中药制剂对其带来的药物损伤也首当其冲。笔者从中药制剂的原料药到成品加工等一系列环节出发,探究其与肝毒性之间的关系,剖析制剂存在肝毒性隐患的机制,为保证药物质量、临床合理用药以及开发出优质低毒的现代化中药制剂提供依据和指导。

Traditional Chinese medicine（ TCM） preparation is one of the most important aspects in the development and quality control of traditional Chinese medicine,and its security problem becomes more and more serious. It is worthy to note that the liver,as the main drug metabolic organ,bears the brunt of the damage caused by TCM preparations. In this paper,the author attempts to explore the relationship between TCM preparations and hepatotoxicity based on the processing chains from crude drugs to the end product.Besides,the author hopes to clarify the underlying mechanism of hepatotoxicity of TCM preparations and provide basis and guidance for the quality control and rational clinical use of the preparations as well as the development of modern TCM preparations with high quality and low toxicity.