香港鹰爪花中倍半萜类化学成分研究

Sesquiterpenes from Artabotrys hongkongensis

综合运用正相硅胶柱色谱、Sephadex LH-20凝胶柱色谱、反相ODS柱色谱以及制备型高效液相色谱等现代色谱分离技术和方法,对番荔枝科鹰爪花属植物香港鹰爪花Artabotrys hongkongensis枝叶中的化学成分进行系统研究。根据化合物的理化性质和波谱数据,并通过与文献对照,鉴定了从香港鹰爪花枝叶的90%乙醇提取物的石油醚萃取部位中分离得到的16个倍半萜类化合物,分别鉴定为:blumenol A(1),4,5-dihydroblumenol A(2),(6R,9S)-3-oxo-a-ionol(3),3-hydroxy-β-ionone(4),dehydrovomifoliol(5),(3R,6R,7E)-3-hydroxy-4,7-megastigmadien-9-one(6),sarmentol F(7),10-oxo-isodauc-3-en-15-oic acid(8),fukinone(9),petasitolone(10),β-eudesmol(11),trans-3β-(1-hydroxy-1-methylethyl)-8aβ-methyl-5-methylenedecalin-2-one(12),10-hydroxyaristolan-9-one(13),aristol-8-en-1-one(14),aristolan-9-en-1-one(15),aristolan-1,9-diene(16)。该研究首次对香港鹰爪花的化学成分进行了系统研究,所有分离得到的化合物均为首次从鹰爪花属植物中分离得到。

The chemical consituents from Artabotrys hongkongensis were separated and purified by column chromatographies with silica gel,Sephadex LH-20,ODS and RP-HPLC. The structures of the isolated compounds were identified on the basis of physicochemical properties and spectroscopic analysis,as well as comparisons with the data reported in the literature. As a result,16 sesquiterpenes were isolated and elucidated as blumenol A（ 1）,4,5-dihydroblumenol A（ 2）,（ 6R,9S）-3-oxo-a-ionol（ 3）,3-hydroxy-β-ionone（ 4）,dehydrovomifoliol（ 5）,（ 3R,6R,7E）-3-hydroxy-4,7-megastigmadien-9-one（ 6）,sarmentol F（ 7）,10-oxo-isodauc-3-en-15-oic acid（ 8）,fukinone（ 9）,petasitolone（ 10）,β-eudesmol（ 11）,trans-3β-（ 1-hydroxy-1-methylethyl）-8aβ-methyl-5-methylenedecalin-2-one（ 12）,10-hydroxyaristolan-9-one（ 13）,aristol-8-en-1-one（ 14）,aristolan-9-en-1-one（ 15）,and aristolan-1,9-diene（ 16）. This is the first study on the chemical consituents of A. hongkongensis,and all compounds were isolated from the genus Artabotrys for the first time.