单体素磁共振波谱在无病灶颞叶癫痫诊断中的应用

VALUE OF SINGLE-VOXEL MAGNETIC RESONANCE SPECTROSCOPY IN THE DIAGNOSIS OF TEMPORAL LOBE EPILEPSY WITHOUT LESIONS IN CONVENTIONAL MRI

目的探讨单体素磁共振波谱(1 H-MRS)在常规磁共振检查未发现病灶的颞叶癫痫诊断中的应用。方法对临床诊断为颞叶癫痫病人33例及年龄、性别与之相匹配的12例正常人行海马区域1 H-MRS检查,检测两组N-乙酰天门冬氨酸(NAA)/肌酸(Cr)、胆碱(Cho)/Cr值,并计算NAA/(Cr+Cho)值。结果癫痫病人患侧、对侧及对照组海马区的NAA/(Cr+Cho)值、NAA/Cr值依次升高,差异有统计学意义(F=15.655、13.033,P<0.01)。结论 1 H-MRS通过显示NAA/Cr、NAA/(Cr+Cho)值的变化,在颞叶癫痫诊断中有一定价值。

Objective To investigate the role and value of single-voxel magnetic resonance spectroscopy（1 H-MRS）in diagnosing patients with temporal lobe epilepsy without lesions in conventional magnetic resonance imaging（MRI）. Methods A total of 33 patients with temporal lobe epilepsy and 12age-and sex-matched healthy subjects were enrolled in the study.1 H-MRS was performed in the ipsilateral and contralateral epileptogenic zones of patients and the hippocampus region of healthy subjects.The ratios of N-acetylaspartate（NAA）/creatine（Cr）,choline（Cho）/Cr,and NAA/（Cr＋Cho）were determined. ResultsThe ratios of NAA/（Cr＋Cho）and NAA/Cr in the ipsilateral epileptogenic zone of patients were lowest,followed by the contralateral epileptogenic zone of patients,and the hippocampus region of healthy subjects,and the differences were statistically significant（F=15.655,13.033;P〈0.01）. Conclusion 1 H-MRS has a certain value in the diagnosis of temporal lobe epilepsy by displaying the changes in NAA/Cr and NAA/（Cr＋Cho）.