小细胞肺癌鼻咽转移的诊治探讨(附1例报告)

DIAGNOSIS AND TREATMENT OF SMALL-CELL LUNG CANCER WITH NASOPHARYNGEAL METASTASIS:A CASE REPORT

目的探讨小细胞肺癌鼻咽转移病人的诊断及相关治疗策略。方法收集1例39岁小细胞肺癌鼻咽转移病人的临床资料,对其治疗及预后进行分析。结果病人经过CT检查、肺组织穿刺活检病理确诊,给予8周期依托泊苷+顺铂方案化疗与肺部、鼻咽部适形放疗交替治疗后,咳嗽、鼻塞症状较前减轻,无鼻涕带血,总体疗效评价为部分缓解。随访至今病人健在,肿瘤无复发。结论小细胞肺癌鼻咽转移病人经过放化疗结合治疗后,可以达到临床部分缓解的状态。

Objective To investigate the strategies for the diagnosis and treatment of small-cell lung cancer with nasopharyngeal metastasis. Methods A 39-year-old male with small-cell lung cancer with nasopharyngeal metastasis confirmed by computed tomography and lung biopsy was enrolled,and was given 8cycles of etoposide＋cisplatin（EP）chemotherapy combined with conformal radiotherapy for the lung and nasopharynx,and then the clinical data were collected to evaluate his clinical outcome.Results After 8cycles of EP chemotherapy combined with conformal radiotherapy for the lung and nasopharynx,the patient showed significantly reduced cough and nasal congestion,had no bloody nose,and achieved partial response（PR）.The patient is alive now,without recurrence. Conclusion The patient with small-cell lung cancer with nasopharyngeal metastasis can achieve PR after a combination of chemotherapy and radiotherapy.