自拟补脾强肾生血汤治疗早中期慢性肾衰贫血的疗效观察

Curative Effect Observation of Self-made Spleen Qiangshen Shengxue Decoction in Treating Anemia of Early Stage Chronic Renal Failure

目的:研究补脾强肾生血汤治疗早中期慢性肾衰贫血的临床疗效,讨论中医药治疗该病的作用机理。方法:选取2012年9月-2014年9月本院西医诊断为肾性贫血,中医辨证为脾肾气血两虚的患者共30例,采用随机数字表法分为观察组和对照组,每组15例。对照组给以重组人促红素注射液(r Hu EPO,CHO细胞)等治疗,对照组在观察组用药基础上给予自拟补脾强肾生血汤口服,两组均治疗56 d。比较患者治疗前后血红蛋白(Hb)、红细胞计数(RBC)、红细胞压积(HCT),血肌酐(Scr)、尿素氮(BUN)及常规检查结果。结果:治疗后观察组RBC、Hb、Scr、BUN水平均优于对照组,差异均有统计学意义(P<0.05),两组治疗前后一般检查结果比较,差异无统计学意义(P>0.05)。结论:采用自拟补脾强肾生血汤治疗早中期慢性肾衰贫血,能够短时间内纠正患者的贫血状况,并可延缓肾功进一步恶化的进程。

Objective： To study the effect of Spleen Qiangshen Shengxue Decoction on the early and middle stage chronic renal failure anemia and discuss the mechanism of TCM treatment.Method： From September 2012 to September 2014, 30 patients diagnosed as renal anemia by western medicine and spleen and kidney qi-blood deficiency by TCM were divided into control group and observation group.The control group was given recombinant human erythropoietin injection （rHuEPO, CHO cells ）and other treatment, observation group was given Spleen Qiangshen Shengxue Decoction on the basis of control group.Both groups were treated 56 days, the changes of hemoglobin （ Hb ）, red blood cell count （ RBC ）, hematocrit （ HCT ）, serum creatinine （ Scr ）, blood urea nitrogen （ BUN ） and result of routine examination.Result： Hb, RBC, Scr and BUN of observation group were all better than those of control group, the differences were statistically significant （ P〈0.05 ）, and there were no significant differences of routine examination result of two groups （ P〉O.05 ） .Conclusion： Spleen Qiangshen Shengxue Decoction can improve the anemia of patients with chronic renal failure, and delay the process of further deterioration of renal function.