早期继续出血的自发性脑出血患者不同时间点氧化应激及炎性介质水平的变化

Changes of oxidative stress and inflammatory mediators in patients with spontaneous intracerebral hemorrhage in early stage

目的探讨早期继续出血的自发性脑出血患者氧化应激及炎性介质水平的变化。方法选取脑出血继续出血患者(观察组)与非继续出血患者(稳定组)、健康对照组(对照组)各48例,分别检测各组不同时间点的丙二醛(MDA)、超氧化物歧化酶(SOD)、肿瘤坏死因子-α(TNF-α)和IL-6的水平变化。结果各时间点观察组、稳定组的MDA、SOD、TNF-α和IL-6水平均明显高于对照组,(P<0.01);与稳定组比较,观察组各时间点的MDA、SOD、TNF-α和IL-6水平显著升高(P<0.05),且在出血早期(24~48 h)氧化应激及炎性反应最为显著(P<0.05)。结论氧化应激及炎性反应可能共同参与了自发性脑出血早期继续出血的发生及发展,可能是继续出血的机制之一。

Objective To study the levels of oxidative stress and the changes of inflammatory mediators in patients with spontaneous intracerebral hemorrhage.Methods 144 patients were equally classified into the observation group,which was comprised of continuous hemorrhage after spontaneous cerebral hemorrhage,and the stable group formed by non-continuous hemorrhage after spontaneous cerebral hemorrhage,and the control group consisted of healthy control group.The changes of malondialdehyde （MDA）,superoxide dismutase （SOD）,tumor necrosis factor alpha （TNF alpha） and IL-6 levels would be separately analyzed at different points in time.Results It was found that the contents of MDA,SOD,TNF alpha and IL-6 in the observation group and the stable group were significantly higher than that in the control group （P〈0.01）,while compared with the stable group,the contents of the observation group at each time point increased significantly （P〈0.05）,and inflammatory reaction was the most significant （P〈0.05） in hemorrhage early （48h） oxidative stress.Conclusion Oxidative stress and inflammatory response might be associated with the occurrence and development of spontaneous intracerebral hemorrhage,and might be one of the mechanisms of continuing hemorrhage.It was prompted for patients that the early intervention was taken,the more profitable could be benefited.