稽留流产发病因素的研究进展

Research progress on pathogenic factors of missed abortion

稽留流产为妇产科较为常见的疾病之一，造成稽留流产发生的因素及危险因素多种多样，可能与染色体异常、妊娠相关因子与蛋白失衡、细胞凋亡、活性氧物质与超氧化物歧化酶、自身免疫性因素、其他因素如噪声、空气污染、电离辐射、与有毒物质密切接触等有关，但具体哪些因素会导致稽留流产及提高稽留流产的发生风险尚无定论。故为了了解该病的发病机制、寻找有效预防和治疗方法，本文就近年来与稽留流产发病相关的因素进行综述。

Missed abortion is a common disease in obstetrics and gynecology with various pathogenic factors, which may be related to chromosomal abnormalities, pregnancy-related factors and protein imbalance, apoptosis, reactive oxygen species and superoxide dismutase, autoimmune factors; other risk factors include noise, air pollution, ionizing radiation and intimate contact with toxic substances. It is uncertain which factors can result in missed abortion or increase the risk of missed abortion. This paper reviewed risk factors associated with missed abortion to help understand the pathogenesis of disease and look for effective prevention and treatment methods.