血尿酸与冠状动脉粥样硬化性心脏病的关系

The relationship between uric acid and coronary artery disease

目的探讨血尿酸水平与冠状动脉粥样硬化性心脏病的关系。方法入选2015年1月至2015年12月于北京友谊医院经冠脉造影证实为冠状动脉粥样硬化心脏病(包括急性心肌梗死和心绞痛)的患者共797例,分析血尿酸水平与患者的自然情况、存在的冠心病危险因素、冠状动脉病变的相关性。结果合并高血压的冠心病患者血尿酸明显高于无高血压的冠心病患者;合并糖尿病的冠心病患者血尿酸显著低于无糖尿病的冠心病患者;吸烟的冠心病患者血尿酸显著高于不吸烟的冠心病的患者;冠状动脉左主干/三支血管病变患者血尿酸水平明显高于单支/双支病变患者血尿酸水平。经logistic分析,仅左主干/三支血管病变与冠心病患者的血尿酸水平独立相关。结论血尿酸水平升高可能是冠状动脉左主干/三支血管病变的独立预测因子。

Objective To investigate the relationship between serum uric acid and coronary artery disease. Methods From Jan 2015 to Dec 2015,797 patients with coronary artery disease（ acute myocardial infarction and angina pectoris） were selected. It was analyzed that correlation between serum uric acid and basic character of patients,risk factors of coronary artery disease and angiographic manifestation. Results The serum uric acid levels of patients with hypertension were significantly higher than those without hypertension（ P〈0. 05）. The patients with diabetes had lower serum uric acid level; Serum uric acid level was significantly higher in smoking group than in non-smoking group（ P〈0. 05）.Logistic regression analysis showed serum uric acid level associated with 3-branch and left main lesions. Conclusion High level of serum uric acid was an independent predictor of 3-branch and left main lesions.