血清ALT对代谢综合征发病影响的分析

Stduy of the relationship between ALT and metabolic syndrome

目的探讨血清丙氨酸氨基转移酶(ALT)对代谢综合征(Met S)的预警作用。方法收集2015年6月至2016年2月体检的525例员工资料。体检项目包括体重指数(BMI)、腰围、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、丙氨酸氨基转移酶、空腹血糖(GLU)和尿酸(UA)。对比Met S组与非Met S组的各项代谢指标;ALT正常组与ALT异常组的主要代谢参数和Met S患病率;不同ALT水平组的代谢指标。结果 (1)与非Met S组比较,Met S组的年龄、体质指数(BMI)、腰围、TG和ALT显著增高,HDL-C明显降低,差异有统计学意义(P<0.05)。(2)ALT异常组Met S患病率为37.17%,明显高于ALT正常组Met S患病率12.75%,两组的患病率比较,差异有统计学意义(P<0.05)。(3)随着ALT含量的增高,年龄、BMI、TG、TC、LDL-C、GLU、UA等均随之升高,HDL-C逐渐降低,不同ALT水平组之间差异具有统计学意义(P<0.05)。结论血清ALT对Met S有着明显的的预警性,两者之间密切相关。

Objective To investigate the effect of serum alanine aminotransferase（ ALT） on metabolic syndrome（ Met S）. Methods A total of 525 employee profiles were collected from June 2015 to February 2016. Body lotness（ BMI）,waist circumference,total cholesterol（ TC）,triglyceride（ TG）,high density lipoprotein cholesterol（ HDL-C）,low density lipoprotein cholesterol（ LDL-C）,alanine amino Transferase,fasting blood glucose（ GLU） and uric acid（ UA）. Results（1）Compared with non Met S group,the age,body mass index（ BMI）,waist circumference,TG and ALT of Met S group were significantly higher than those of non Met S group,and the difference was statistically significant（ P〈0. 05）. The prevalence of Met S was 37. 17% in ALT abnormal group. The prevalence of Met S was 12. 75% in normal ALT group,and the prevalence of Met S was significantly different（ P〈0. 05）. The levels of BMI,TG,TC,LDL-C,GLU and UA increased with the increase of ALT content,HDL-C decreased gradually,and the difference was statistically significant（ P〈0. 05）. Conclusion Serum ALT has a significant early warning to Met S,which is closely related to both.