结直肠癌患者血清壬基酚含量测定及临床意义

Concentration detection and clinical study of nonylphenol in serum of patients with colorectal cancer

目的 检测结直肠癌患者及健康体检人群体内血清壬基酚（NP）浓度，探讨NP含量在结直肠癌患者与健康人群血清中的差异。方法选择经病理诊断明确的结直肠癌患者141例作为观察组，包括男88例，平均年龄60.28岁，女53例，平均年龄64.74岁。对照组来自同期我院体检中心的健康体检者，共141例，其中男88例，平均年龄61.20岁；女53例，平均年龄63.57岁。运用高效液相色谱法检测两组人群血清中NP含量。 结果 男性、女性、总体结直肠癌患者血清NP水平分别为（237.27±36.93）、（232.65±34.87）、（232.65±34.87） ng/ml，与相应对照组血清NP水平[（214.08±26.39）、（210.86±18.88）、（212.47±22.64） ng/ml]比较，均呈现出增高趋势，血清NP浓度在结直肠癌组显著高于对照组，差异有统计学意义（P＝0.000）。结论 结直肠癌的发生、发展可能与人体内环境内分泌干扰物NP含量升高相关。

Objective To determine the serum nonylphenol （NP） concentrations in colorectal cancer patients and healthy populations. Methods 141 patients who were diagnosed as colorectal cancer served as the observation group （88 males with average age of 60.28 years, and 53 females with average age of 64.74 years）, and 141 healthy people as control group （88 males with average age of 61.2 years, and 53 females with average age of 63.57 years）. Serum levels of NP were determined by high performance liquid chromatography. Results In colorectal cancer group, the serum neopterin levels of males [（237.27±36.93） ng/ml], females [（232.65±34.87） ng/ml] and both sexes [（232.65±34.87） ng/ml] were significantly increased as compared with the control group [（214.08±26.39） ng/ml for males, （210.86±18.88） ng/ml for females, and （212.47±22.64） ng/ml for both sexes] （P=0.000）.Conclusion The occurrence and development of colorectal cancer may be related to the increased content of environmental endocrine disruptor NP in human body.