摘要
目的 探讨叉头框蛋白M1（FoxM1）与中心体相关激酶2（Nek2）在肾癌组织中的表达及意义。
方法 随机选取通过手术切除的肾细胞癌组织及癌旁组织标本56例，标本均经病理检查确诊，应用Western blot法检测肾癌组织和癌旁组织中FoxM1蛋白和Nek2的表达。
结果 FoxM1蛋白在肾癌组中的表达（1.16±0.25）较癌旁组（0.26±0.08）高（t＝39.083，P＝0.000），Nek2在肾癌组中的表达（1.04±0.18）较癌旁组（0.17±0.05）高（t＝34.161，P＝0.000），肾癌组织中FoxM1和Nek2的表达呈正相关（r＝0.869，P＝0.000）。结论 FoxM1和Nek2在肾癌中呈高表达，且两者表达呈正相关，联合检测FoxM1和Nek2可能有利于肾癌的临床诊断和预后判断。
Objective To investigate the expression and significance of forkhead box protein M1 （FoxM1） and NIMA-related kinase 2 （Nek2） in kidney cancer tissues.
Methods Fifty-six specimens through surgical removal of kidney cancer and adjacent tissues were randomly choosen. The specimens were diagnosed by pathology. The expression of FoxM1 and Nek2 wsd detected by immunoblotting in kidney cancer and adjacent tissues.
Results The expression of FoxM1 protein in kidney cancer （1.16±0.25） was higher （t=39.083, P=0.000） than that in the adjacent group （0.26±0.08）, the expression of Nek2 in kidney cancer （1.04±0.18） was higher （t=34.161, P=0.000） than that in the adjacent tissues （0.17±0.05）, and the expression of FoxM1 and Nek2 in kidney cancer tissues was positively correlated （r=0.869, P=0.000）.Conclusion FoxM1 and Nek2 were highly expressed in kidney cancer, and the expression of FoxM1 and Nek2 was positively correlated. FoxM1 and Nek2 could be beneficial to the diagnosis and prognosis of kidney cancer.
出处
《中华实验外科杂志》
CSCD
北大核心
2017年第9期1580-1581,共2页
Chinese Journal of Experimental Surgery
